WV-INBRE:APPALACHIAN CARDIOVASCULAR RESEARCH NETWORK (ACORN)

这个子项目是利用资源的许多研究子项目之一。 由NIH/NCRR资助的中心拨款提供。对子项目的主要支持 子项目的首席调查员可能是由其他来源提供的， 包括美国国立卫生研究院的其他来源。为子项目列出的总成本可能 表示该子项目使用的中心基础设施的估计数量， 不是由NCRR赠款提供给次级项目或次级项目工作人员的直接资金。 心血管疾病和肥胖是西弗吉尼亚州(WV)和肯塔基州(KY)的重大健康问题。西弗吉尼亚州和肯塔基州的心脏病死亡率分别排在第44位和第47位，在50个州和哥伦比亚特区中肥胖率最高(分别为第50位和第51位)。 阿巴拉契亚心血管研究网络(ACCON)的主要目标是：(1)发现心血管疾病的分子、遗传和环境原因；(2)为在西弗吉尼亚-INBRE的领先和本科机构进行心血管研究的教师提供指导、遗传资源和现代技术；(3)支持西弗吉尼亚州的社区研究。橡子团队由Donald Primerano博士领导，由项目调查人员、顾问和导师组成，他们在基因图谱、统计遗传学、基因分型和心血管生理学方面具有专业知识。 橡子将监督或指导以下关于心血管疾病的研究，并为本科生项目调查人员提供指导： (A)他汀类药物对内皮细胞功能的作用机制(SPID#25)。P.I.罗伯特·克莱斯伯格，西自由大学。导师：马歇尔大学N·桑塔纳姆。 (B)USF1在调节胆固醇和甘油三酯合成中的作用(学院研究发展奖)，费尔蒙州立大学Sarah Dodson。导师：D.普里梅拉诺。 (C)家族性混合性高脂血症的遗传基础(SPID#26)。该项目由D.Primerano指导，需要WV-INBRE项目中几位专家的参与：J.Denvir博士、数据库经理、遗传分析师Yulia Dementieva、William Neal医学博士心血管儿科医生和研究护士。 (D)西弗吉尼亚大学的Sara Knox博士正在研究饮食对人类白细胞和内皮细胞基因表达模式的影响。 (E)阿巴拉契亚地区冠心病患者的心外膜脂肪生物标记物(SPID#36)。项目主管N.Santanam博士。马歇尔大学。 在WV-INBRE II中，我们将通过(1)增加一名全职招募协调员来指导研究护士、完善IRB方案和微调招募策略，(2)增加肯塔基大学青少年医学系作为招募地点，以及(3)将参与者礼品卡的金额增加到30美元，从而加强患者在人体研究中的招募。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. Primary support for the subproject and the subproject's principal investigator may have been provided by other sources, including other NIH sources. The Total Cost listed for the subproject likely represents the estimated amount of Center infrastructure utilized by the subproject, not direct funding provided by the NCRR grant to the subproject or subproject staff. Cardiovascular disease and obesity are significant health problems in West Virginia (WV) and Kentucky (KY). WV and KY rank 44th and 47th respectively in heart disease death rates and have the two highest rates of obesity (50th and 51st respectively) among the 50 states and the District of Columbia. The primary goals of the Appalachian Cardiovascular Research Network (ACoRN) are to (1) discover the molecular, genetic and environmental causes of cardiovascular disease, (2) provide mentorship, genetic resources and modern technology to faculty conducting cardiovascular research at the lead and undergraduate institutions in WV-INBRE and (3) support community based research in WV. The ACoRN team is directed by Donald Primerano PhD and consists of project investigators, consultants and mentors with expertise in genetic mapping, statistical genetics, genotyping and cardiovascular physiology. ACoRN will oversee or guide the following research studies on cardiovascular disease and provide mentorship to undergraduate project investigators: (a) Mechanism of Action of Statins on Endothelial Cell Function (SPID #25). P.I. Robert Kreisberg, West Liberty University. Mentor: N. Santanam, Marshall University. (b) Role of USF1 in the Regulation of Cholesterol and Triglyceride Synthesis (Faculty Research Development Award) Sarah Dodson, Fairmont State University. Mentor: D. Primerano. (c) The Genetic Basis of Familial Combined Hyperlipidemia (SPID #26). This project is directed by D. Primerano and requires the input of several experts within the WV-INBRE program: J. Denvir PhD, database manager, Yulia Dementieva, genetic analyst, William Neal MD cardiovascular pediatrician, and research nurses. (d) Dr. Sara Knox at West Virginia University is studying the effect of diet on gene expression patterns in human leukocytes and endothelial cells. (e) Epicardial Fat Biomarkers in Patients with Coronary Artery Disease in the Appalachian Region (SPID #36). Project Director N. Santanam PhD. Marshall University. In the WV-INBRE II, we will strengthen patient recruitment into human studies by (1) adding a full time recruitment coordinator to guide the research nurses, complete IRB protocols and fine tune recruitment strategies, (2) adding the Department of Adolescent Medicine at the University of Kentucky as a recruitment site, and (3) increasing the amount of participant gift cards to $30.