GRIN LENS ROD BASED PROBE FOR OFFICE-BASED OCT OF THE HUMAN LARYNX

这个子项目是利用资源的许多研究子项目之一。 由NIH/NCRR资助的中心拨款提供。对子项目的主要支持 子项目的首席调查员可能是由其他来源提供的， 包括美国国立卫生研究院的其他来源。为子项目列出的总成本可能 表示该子项目使用的中心基础设施的估计数量， 不是由NCRR赠款提供给次级项目或次级项目工作人员的直接资金。 光学相干层析成像(OCT)是一种发展中的非侵入性成像手段，它将干涉测量与低相干光相结合，在混浊的介质(如活体组织)中产生高分辨率图像，并已被用于手术内窥镜检查中的喉部成像。在办公室环境中清醒的患者的OCT喉部成像一直受到限制，因为存在一些挑战，包括患者和医生的移动以及喉咙在颈部深处的位置。本项目的目标是设计一种新型的OCT采样设备，能够在清醒的办公室进行刚性喉镜检查时捕获活体图像。我们提出了一种基于GRIN透镜的探头的新设计，该探头能够在典型的办公室喉镜检查中使用频域OCT来捕捉人类喉部的图像。提出了一种新型的具有恒定光延时的快速扫描和动态聚焦的探头。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. Primary support for the subproject and the subproject's principal investigator may have been provided by other sources, including other NIH sources. The Total Cost listed for the subproject likely represents the estimated amount of Center infrastructure utilized by the subproject, not direct funding provided by the NCRR grant to the subproject or subproject staff. Optical coherence tomography (OCT) is an evolving noninvasive imaging modality that combines interferometry with low-coherence light to produce high resolution images in turbid media such as living tissues, and has been used to image the larynx during surgical endoscopy. OCT imaging of the larynx in awake patients in an office setting has been limited because several challenges exist including patient and physician movements and the position of the larynx deep within the neck. The objective of this project is to design a novel OCT sampling device capable of capturing in vivo images during awake office-based rigid laryngeal endoscopy. We propose a novel design of a GRIN lens based probe capable of capturing images of the human larynx by use of spectral domain OCT during a typical office based laryngoscopy examination. A novel probe capable of both fast scanning and dynamic focusing with a constant optical delay is presented.