Graduate Training at the Chemistry Biology Interface

这项建议是对化学-生物接口的一种更新申请 马里兰大学巴尔的摩分校(UMBC)研究生课程。这个项目是在密歇根州立大学启动的 1998年，并由该大学单独资助，直到2004年7月首次获奖。该计划的启动是为了 为化学、生物化学和生物专业的学生提供跨学科培训的机会。到目前为止 除了19名博士生外，还有13名博士生获得了培训助学金的资助 那些从大学获得了更多津贴的人。密歇根州立大学CBI项目的学生是 四个博士学位项目：化学、生物学、分子和细胞生物学及联合生物化学 由密歇根大学化学系和生物化学和分子系共同实施的计划 马里兰大学巴尔的摩分校(UMB)市中心校区的生物学。跨学科培训是 通过几种方式实现，一是在实验室轮换相反学科的可能性， 另一门学科的高级课程，以化学715课程的形式每两周开一次会 在化学-生物界面，学生们参与关于职业问题的讨论，学习 如何从各种“热门”话题领域进行研究演讲、回顾和展示文献，以及 主持来访研讨会的演讲者。更重要的是，程序增加了一个新功能，因为 初始资助期，有相反学科导师的正式培训机会，具体而言 由学生的研究导师结合培训机会为每个学生设计 门托。新的培训机会旨在给学生提供更有意义的经验 除了加强他们的学位论文研究。目前学生的一些研究项目包括： “用于激活乳腺癌特异性CD4+T细胞的新型MHCⅡ限制性多肽”，“蛋白质-蛋白质” Rob和Soxs的相互作用及其在大肠杆菌应激防御反应系统中的作用 新型G蛋白偶联受体黑素蛋白的磷酸化依赖失活“， 《S100B与抑制P53结合的小分子结合的特征》、《APE1在 DNA糖基酶的刺激“，”TDG和APE1之间关系的特征“，以及 《氨基黄酮类抗癌药物活性代谢物的化学表征》。是我们节目独一无二的， CBI的学生从一年级到毕业，无论他们是否在 培训补助金，从而确保持续的指导、指导和接触跨学科的科学。 相关性(请参阅说明)： 最近，包括美国国立卫生研究院在内的许多资助机构都建立了新的项目来资助跨学科 随着许多科学领域的融合，研究也在不断地融合。在多学科领域接受培训的学生 有市场，也更有可能在自己的独立职业生涯中取得成功。的基本理念 CBI项目旨在为优秀的研究生提供跨学科体验的机会 培训除了传统的深入研究培训外，还针对自己的学科开展培训。

This proposal is a renewal application for the Chemistry-Biology Interface Graduate program at the University of Maryland, Baltimore CO (UMBC). This program was started at UMBC in 1998, and solely funded by the university until the initial award in July 2004. The program was initiated to provide opportunities for cross-disciplinary training for chemistry, biochemistry and biology students. To date thirteen Ph.D. students have been funded by the training grant in addition to another nineteen Ph.D. students that have received increased stipends from the university. Students in the UMBC CBI program are part of four Ph.D. degree programs; Chemistry, Biology, Molecular and Cellular Biology and the joint Biochemistry program run by the Chemistry department at UMBC and the Department of Biochemistry and Molecular Biology at the University of Maryland Baltimore (UMB) downtown campus. Cross-disciplinary training is accomplished in a number of ways, one, the possibility for a rotation in a laboratory in the opposite discipline, an upper level course in the opposite discipline, biweekly meetings in the form of a class CHEM 715, "Issues at the Chemistry-Biology Interface", where the students participate in discussions on career issues, learn how to give research talks, review and present literature from a wide variety of "hot" topic areas, as well as to host visiting seminar speakers. More significantly, a new feature of the program has been added since the initial funding period, a formal training opportunity with a mentor in the opposite discipline, specifically designed for each student by the student's research mentor in conjunction with the training opportunity mentor. The new training opportunity is designed to give the student a more meaningful experience in addition to enhancing their dissertation research. Some of the current students' research projects include: "Novel MHC ll-restricted peptides for activating breast cancer-specific CD4+ T cells", "Protein-Protein Interactions of Rob and SoxS and their Role in Stress Defense Response Systems in E. coli", "Investigation of phosphorylation dependent deactivation of the novel G protein coupled receptor melanopsin", "Characterizing S100B Bound to Small Molecules that Inhibit p53 Binding", "The Importance of APE1 in the Stimulation of DNA Glycosylases", "Characterization of the Relationship between TDG and APE1", and "Chemically characterizing the active metabolite of aminoflavone anticancer drugs". Unique to our program, the CBI students participate from year one until they graduate, regardless of whether or not they are on the training grant, thus insuring continual mentorship, guidance and exposure to cross-disciplinary science. RELEVANCE (See instructions): Recently many funding agencies, including NIH, have instituted new programs to fund cross-disciplinary research as many areas of science are merging. Students trained in multidisciplinary areas are more marketable and also more likely to be successful in their own independent careers. The basic philosophy of the CBI program is to provide outstanding graduate students the opportunity to experience cross-disciplinary training in addition to the traditional in-depth research training in their own discipline.