Research Training - Genetics of Substance Abuse

请参阅说明)： 这项提案正在寻求通过机构培训赠款继续支持一项针对初中生的培训方案 以及博士后研究员，他们将从事专注于研究基因对人的影响的研究事业 滥用药物。IBG的教职员工是杰出的和积极的研究人员，IBG的科学家们积极地 对药物滥用的遗传影响进行了40多年的研究。与主要药物滥用有关 人类和动物行为遗传学的研究项目目前都在进行中。技术的应用 生物计量学、统计学和数量遗传技术与数量性状基因座的开发 方法允许对调节复杂性状的基因进行定位和识别。来自这样的信息 分析，以及神经化学、神经药理学、神经生理学和分子遗传学 研究，将提供对与行为相关的基因功能的理解。主要研究项目现在正在进行 在人类和动物行为遗传学方面取得进展，包括大规模的国家合作研究 积累可用于药物滥用研究的DNA存储库和丰富的表型数据集。设施 可用于基因分析，包括全基因组分析、基因功能和表达研究，以及 行为、生化和神经生理学研究。申请资金支持4名博士后和2名博士后 博士后实习生，为期5年。博士前实习生从 行为遗传学方面的合作学术单位和认证。培训中的学历要求 课程包括行为遗传学、数量遗传学和生物测定遗传学、理论和 基于计算机的统计学、分子遗传学、生物信息学和基因组学，负责 关于行为和临床表型的研究和课程。附加要求根据 学位授予学术单位。研究经验是培训不可或缺的一部分。博士后实习生也 追求一个正式的项目，强调个人研究以及在分子和 数量行为遗传学。为心理健康研究事业做准备的其他活动包括： 监督学生和/或技术人员，主持研讨会演讲者，客座演讲，周刊 俱乐部，并强制参加一个关于负责任的研究行为的课程。 相关性(请参阅说明)： 这项建议是为了培养能够对我们理解基因的研究做出重大贡献的科学家。 助长了药物滥用的脆弱性。这一理解将导致新的 预防和减轻药物滥用的方法。

Seeinstructions): This proposal is seeking continued support, via an institutional training grant, for a training program for pre- and postdoctoral fellows who will pursue research careers that focus on the study of genetic influences on substance abuse. The IBGfaculty is distinguished and active in research and IBG scientists have actively pursued studies of genetic influences on substance abuse for over 40 years. Major substance abuse-related research projects are now in progress in both human and animal behavior genetics. The application of biometrical, statistical, and quantitative genetic techniques and the development of quantitative trait loci methods allow the mapping and identification of genes that regulate complex traits. Information from such analyses, along with neurochemical, neuropharmacological, neurophysiological, and molecular genetic studies, will provide an understanding of gene function related to behavior. Major research projects are now in progress in both human and animal behavior genetics, including large scale national collaborative studies amassing DNA repositories and rich phenotypic data sets available for studies of substance abuse. Facilities are available for genotype assay, including genome-wide assays,gene function and expression studies, and behavioral, biochemical, and neurophysiological studies. Funds are requested to support 4 predoctoral and 2 postdoctoral trainees over a total period of 5 years. Predoctoral trainees receive doctorate degrees from a cooperating academic unit and certification in behavior genetics. Academic requirements in the training program include training in behavior genetics, quantitative and biometrical genetics, theoretical and computer-based statistics, molecular genetics, bioinformatics and genomics, responsible conduct of research, and courses on behavioral and clinical phenotypes. Additional requirements vary according to the degree granting academic unit. Research experience is an integral part of training. Postdoctoral trainees also pursue a formalized program that emphasizes individual research as well as competence in molecular and quantitative behavior genetics. Other activities in preparation for research careers in mental health include: supervision of students and/or technicians, hosting of seminar speakers, guest lecturing, a weekly journal club, and mandatory attendance in a course on the responsible conduct of research. RELEVANCE (See instructions): This proposal is to train scientists who will be able to contribute significantly to our understanding of genetic contributions to the vulnerability to develop substance abuse. This understanding will lead to new approaches to the prevention and alleviation of substance abuse.