Inhibiting tumour growth by targeting EphA3 and disrupting tumour stromal and vascular microenvironment
Inhibiting tumour growth by targeting EphA3 and disrupting tumour stromal and vascular microenvironment
批准号:
nhmrc : 1049942
负责人:
A/Pr Martin Lackmann
金额:
$43.02万
依托单位:
依托单位国家:
澳大利亚
项目类别:
Project Grants
财政年份:
2013
资助国家:
澳大利亚
项目状态:
已结题
起止时间:
2013-01-01 至 2015-12-31
中文摘要
肿瘤由癌细胞、肿瘤血管和结缔组织组成,所有这些都与正常组织不同。许多构成肿瘤血管和结缔组织的细胞在肿瘤的初始生长和随后的扩散期间从骨髓中募集。我们的研究将检查肿瘤发展过程中这些细胞上EphA3受体的存在和功能,并评估我们的抗EphA3抗体如何通过靶向基质和血管系统抑制肿瘤生长。
英文摘要
Tumours consist of cancer cells, tumour blood vessels and connective tissue, all of which are different to normal tissues. Many of the cells making up tumour vessels and connective tissue are recruited, during initial growth and subsequent spreading of tumours, from the bone marrow. Our research will examine the presence and function of the EphA3 receptor on these cells during tumour development and assess how our anti-EphA3 antibody inhibits tumour growth by targeting stroma and vasculature.
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会议论文
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The role of protein tyrosine phosphatases regulating Eph RTK-signalling and modulating invasive tumour cell properties.
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Functional analysis of the molecular switch that regulates ADAM10-mediated cleavage of RTK ligands in tumour cells.
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Stage II in the development of Eph/ephrin based tumor targeting reagents: Optimisation of drug efficacy and delivery
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Development of anti-metastatic and tumour targeting reagents by design of inhibitors to specific Eph/ephrin cell-cell
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依托单位:
Development and evaluation of biological reagents targeting and inhibiting function of the EphA3 receptor on tumor cells
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依托单位:
Signal transduction pathways of EphA receptor tyrosine kinases
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