CARIBBEAN PRIMATE RESEARCH CENTER

描述（由申请人提供）：这笔赠款将提供持续的NIH支持，以维持加勒比灵长类动物研究中心（CPRC）。该中心由四个综合设施组成：（1）圣地亚哥岛，一个独特的印度恒河猴自由放养的岛屿殖民地（Macaca mulatta）;（2）位于圣胡安外10英里处的CPRC总部Sabana Seca野战站，它以各种户外配置安置了来自圣地亚哥岛殖民地的恒河猴，用于生物医学和行为研究，这些研究在免费的情况下是不可行的。该实验室位于：（1）位于哥伦比亚特区圣胡安市（圣胡安）的一个动物实验室;（2）位于哥伦比亚特区圣胡安市的一个动物实验室;（3）位于圣胡安市医学科学院（MSC）的病毒学和遗传学实验室（LVG）;以及（4）位于圣胡安市医学科学院（MSC）的灵长类动物形态学和遗传学实验室（LPMG）。如本提案所述，CPRC分为四个互补和综合的部门：灵长类动物资源，病毒学和遗传学，行为和神经科学，以及灵长类动物形态学和遗传学。本申请中要求的资金仅用于维护CPRC灵长类动物资源的基本基础设施，这些基础设施用于支持美国各地的许多研究项目。这项核心拨款亦可让研究中心寻求额外支援，与内地及国际研究人员开展合作研究项目。在NIH的持续支持下，CPRC将继续成为重要的国家研究资源，并将能够为NIH赞助的研究项目提供具有明确遗传和病毒学背景的健康印度恒河猴。 公共卫生相关性（由申请人提供）：CPRC仍然是一个平台，支持美国各地许多公共卫生系统赞助的研究项目。该中心提供印度原产的恒河猴，作为开发有效治疗人类疾病的模型。有了NCRR对这笔赠款的必要支持，CPRC将继续成为全国最大的SPF和艾滋病和其他生物医学研究项目所需的常规恒河猴的提供者之一，以及行为和生物医学研究所需的宝贵研究资源。

DESCRIPTION (provided by applicant): This grant will provide continued NIH support to maintain the Caribbean Primate Research Center (CPRC). The CPRC consists of four integrated facilities: (1) Cayo Santiago, a unique free-ranging island colony of Indian-origin rhesus monkeys (Macaca mulatta); (2) the Sabana Seca Field Station, the CPRC's headquarters located 10 miles outside of San Juan, that houses rhesus monkeys derived from the Cayo Santiago colony in various outdoor configurations for biomedical and behavioral studies that are not feasible on free-ranging animals; (3) the Laboratory of Virology and Genetics (LVG), located on the Medical Sciences Campus (MSC), in San Juan; and (4) the Laboratory of Primate Morphology and Genetics (LPMG), which is also located on the MSC, and houses the CPRC Skeletal Collections, unique assemblages of nonhuman primate skeletons for genetic, developmental, pathological and anatomical research. As described in this proposal, CPRC is organized into four complementary and integrated divisions: Primate Resources, Virology and Genetics, Behavior and Neurosciences, and Primate Morphology & Genetics. Funds are requested in this application only to maintain CPRC basic infrastructure of Primate Resources, which are used to support numerous research projects across the United States. This core grant will also allow CPRC to seek additional support to launch collaborative research projects with mainland and international investigators. With continued NIH support, the CPRC will remain a significant national research resource and will be able to provide healthy Indian-origin rhesus monkeys of defined genetic and virological background to NIH-sponsored research programs. PUBLIC HEALTH RELEVANCE (provided by applicant): The CPRC continues to be a platform that supports numerous PHS-sponsored research projects throughout USA. The Center provides Indian-origin rhesus monkeys which serve as models for the development of effective treatments against human diseases. With the needed NCRR support to this grant, the CPRC will continue to be one of the largest nationwide providers of SPF and of conventional rhesus monkeys required for AIDS and for other biomedical research projects and a valuable research resource needed for behavioral and biomedical studies.