Biostatistics Core

生物统计核心为所有SARC孢子项目提供最先进的统计支持 调查人员。SARC孢子的总体目标是更好地了解肉瘤的病因及其 组织学，并开发生物标记物和肉瘤患者的新治疗选择。这个 生物统计核心将在设计、分析和设计的所有方面提供统计咨询和合作 临床试验和实验室实验的解释。核心人员将与项目密切合作 领导确保生物统计核心提供最先进的统计支持。 生物统计核心的主要目标是： 1.提供研究设计并审查所有实验室、动物和临床研究，包括可行性 评估、能量分析和样本量估计； 2.在项目数据分析、结果解释和撰写最终研究报告方面进行协作 和手稿； 3.促进基础科学实验数据的前瞻性收集、录入和质量控制； 并与临床试验核心合作，促进临床数据的质量控制；以及 4.为试验设计和数据分析开发和评估统计方法。 为了确保这些目标的实现，生物统计的核心人员之间保持持续、定期的沟通 需要核心、孢子项目和其他核心，项目和核心之间的定期每周会议呼叫 领导人将审查临床试验、实验室研究和数据分析的进展情况，确保问题得到解决 认可/解决并通知发展的领导者。

The Biostatistics Core provides state-of-the-art statistical support for all SARC SPORE projects and investigators. The overall goal ofthe SARC SPORE is to better understand the etiology of sarcoma and its histologies, and to develop biomarkers and M new treatment options for sarcoma patients. The Biostatistics Core will provide statistical consultation and collaboration on all aspects of design, analysis and interpretation of the clinical trials and laboratory experiments. Core personnel will work closely with project leaders to ensure that the Biostatistics Core provides state-of-the-art statistical support. The primary objectives of the Biostatistics Core are to: 1. Provide study design and review all laboratory, animal, and clinical studies including feasibility assessment, power analysis, and sample size estimation; 2. Collaborate in the project data analysis, interpretation of results, and writing of final study reports and manuscripts; 3. Facilitate prospective collection, entry and quality control of data for the basic science experiments; and collaborate with the clinical trials core to facilitate quality control of clinical data; and 4. Develop and evaluate statistical methods for experimental design and data analysis. To ensure those aims are met, constant, regular communication among core personnel of this Biostatistics Core, SPORE projects and other Cores is needed, Regular weeKly conference calis among project and core leaders will review progress on clinical trials, laboratory studies and data analysis, ensure issues are recognized/addressed, and apprise leaders of developments.