PAHs: New Technologies and Emerging Health Risks

多环芳烃（PAHs），重新出现的环境污染物的关注，发现在 超级基金地点和城市环境是在燃烧碳基能源的过程中形成的，例如，柴油， 汽油、煤、石油以及烹饪或烟草烟雾中的物质。全球能源需求增加 多环芳烃的生产，导致人类接触。这个新的SBRP汇集了一个多学科的团队， 来自一个学术机构和一个国家实验室，在多环芳烃和环境方面有多年的经验， 健康问题。我们设计了6个创新和令人兴奋的项目，并探索新的机制， 多环芳烃及其对人类健康的影响。这些项目的重点是（1）皮肤癌和经胎盘癌中的多环芳烃 和预防方法;（2）使用小鼠和人类构建第一个PAH PBPK模型;（3） 对多功能模型（斑马鱼）发育的不利影响;（4）被动采样的发展 装置，部署在超级基金的网站，在斑马鱼模型测试;（5）分析方法的发展 用于跟踪另一种新出现的潜在健康威胁，纳米材料，以及（6）确定PAH成分 和大气沉降（在中国，燃煤发电厂和汽车的使用正在爆炸式增长）及其影响 多环芳烃在运输到美国的过程中“老化”;重点将放在高度暴露的人群（中国人和土著人 在美国的美国人）。研究支持核心是统计和生物信息学核心， 分析化学核心，它提供了一个连续的成功，在数据存储，分析和 分享和使用PAH标准和分析。项目对核心的共同使用确保了高 可靠性和一致性。研究翻译中心（RTC）的人员，由医学博士指导，M.P.H. 拥有多年的公共卫生经验，并作为研究和人口之间的渠道， 暴露的担忧。社区外展核心与RTC密切相关， 关注PAH暴露的社区，核心已经开发了创造性的场所， 与公众交流科学成果。最后，行政团队历史悠久 成功管理NIEHS多研究者赠款并获得强有力的机构支持。 这些项目的创新性，多环芳烃的高度重要性，紧密结合，共享 资源和方法，将科学研究成果提炼到受影响人群中的能力， 长期的成功管理历史为这一新的SBRP提供了我们相信评审员会提供的东西。 判断是许多令人兴奋的和重要的优势，在所采取的方法高度创新。

Polycyclic Aromatic Hydrocarbons (PAHs), re-emerging environmental pollutants of concern, found at Superfund sites and urban settings, are formed in the burning of carbon-based energy sources, e.g., diesel, gasoline, coal, petroleum and in cooking or tobacco smoke. Increasing energy needs world-wide contribute to PAH production, resulting in human exposures. This new SBRP brings together a multi-disciplinary team, from an academic institution and a National Laboratory, with years of experience in PAHs and environmental health issues. We designed 6 projects that are innovative and exciting, and that explore new mechanisms of PAHs and their impact on human health. The projects focus on (1) PAHs in skin and transplacental cancer and prevention approaches; (2) construction of the first PAH PBPK model using both mice and humans; (3) adverse effects on development in a versatile model (zebrafish); (4) development of passive sampling devices, deployed at Superfund sites, testable in the zebrafish model; (5) development of analytical methods for tracking another emerging potential health threat, nanomaterials, and (6) determining PAH composition and atmospheric deposition (in China, coal-fired energy plants and automobile use is exploding) and effects of PAHs "aging" in transport to the U.S.; the focus will be on highly exposed populations (Chinese and Native Americans in the U.S.). The Research Support Cores are the Statistics and Bioinformatics Core, and the Analytical Chemistry Core, which provide a continuum critical to success in data storage, analysis and sharing, and use of PAH standards and analysis. Common use of the cores by projects ensures high reliability and consistency. Personnel in the Research Translation Core (RTC), directed by an M.D., M.P.H., have years of experience in public health and serve as a conduit between research and populations with exposure concerns. The Community Outreach Core, tied closely to the RTC, has experience with Tribal Communities concerned about PAH exposure, and the Core has developed creative venues for communication of scientific results with the general public. Finally, the administrative team has a long history of successful management of NIEHS multi-investigator grants and acquisition of strong institutional support. The innovative nature of these projects, the high significance of PAHs, the tight integration, the shared resources and approaches, the demonstrated ability to distill scientific studies to impacted populations and the long history of successful administration provide this new SBRP with what we trust the reviewers will judge to be many exciting and important strengths with high innovation in the approaches taken.