Inflammatory Biomarkers in Pediatric Obesity and Diabetes: Research and Mentoring

描述(由申请人提供)：Pietro Galassetti，医学博士，加州大学欧文分校儿科和药理学系副教授，也是临床和翻译科学研究所(ICTS，前身为GCRC)新陈代谢和生物营养核心的主任。在过去的20年里，他一直参与以患者为中心的研究，目前是两项外部资助(包括NIH RO1)的PI，专注于共同主题的项目，即确定导致代谢紊乱状态并发症早期发展的生化机制，如肥胖症、代谢综合征、1型糖尿病(T1 DM)和2型糖尿病(T2 DM)。他目前的主要具体研究课题是：a)开发一种通过对呼出的挥发性有机化合物进行综合分析来测量血糖、胰岛素和血脂的非侵入性技术；b)肥胖和代谢综合征儿童运动期间炎症和氧化应激机制的定义。这些项目完全以患者为导向，本质上是翻译性的。在未来几年，为这些项目的发展维持和改善充足的研究资金将是具有挑战性的。通过这项申请，加拉塞蒂博士需要50%的专业工作支持，其中一半，即他总时间的25%，将致力于完成上述两个研究领域的新颖、探索性实验，旨在促进获得额外的研究资金。Galassetti博士在高影响力的期刊上发表了大量关于翻译研究主题的文章(在过去5年中只发表了35篇同行评议的论文，总共78篇)；他担任了20多种科学期刊、几个赠款资助机构(NIH、JDRF和其他国家和国际基金会)的审阅人。加拉塞蒂博士的大部分时间都被辅导活动占据，这些活动包括：a)直接辅导加州大学洛杉矶分校的住院医生、研究员、医学和研究生，他们参与加拉塞蒂博士的研究项目；b)辅导试图发展独立研究路线的初级教员；c)辅导初级调查人员，与其他PI一起参与临床翻译项目，要求加拉塞蒂博士提供专业知识；D)通过结构化的UCI机制提供指导，如Bio 199临床研究课程、UCI临床试验课程的实习机会、UCI指导医学生临床研究计划、新生儿研究员奖学金监督委员会等。他的许多受训人员根据最近的研究结果与人合著摘要和论文，其中一些人在他的指导下获得了地区和国家研究奖。因此，所需薪金支助的其余25%将用于继续和扩大这些辅导活动。总而言之，加拉塞蒂博士完全致力于以患者为导向的研究事业。这项奖励将大大减少他目前繁重的行政和服务职责，并按比例增加用于翻译科学指导和研究活动的受保护时间。

DESCRIPTION (provided by applicant): Pietro Galassetti, MD PhD, is an Associate Professor in the Departments of Pediatric and Pharmacology of the University of California, Irvine, where he also serves as Director of the Metabolism and Bionutrition Core at the Institute for Clinical and Translational Science (ICTS, formerly GCRC). He has been involved in Patient Oriented Research for the last 20 years, and currently is PI on 2 extramural grants (including an NIH RO1), focused on projects with the common theme of defining the biochemical mechanisms underlying the early development of complications in dysmetabolic states, such as obesity, metabolic syndrome, type 1 (T1DM) and type 2 diabetes (T2DM). His current main specific research topics are: a) The development of a non-invasive technique for the measurement of plasma glucose, insulin and lipids through integrated analysis of exhaled volatile organic compounds; b) The definition of inflammatory and oxidative stress mechanisms during exercise in children with obesity and metabolic syndrome. These projects are fully patient-oriented and translational in nature. Maintaining and improving adequate research funding for the evolution of these projects will be challenging in coming years. With this application, support for 50% of Dr. Galassetti's professional effort is requested, of which half, or 25% of his total time, will be devoted to completing novel, exploratory experiments in the 2 research areas outlined above, aimed at facilitating the acquisition of additional research funding. Dr. Galassetti has published extensively on translational research topics in high-impact journals (35 published peer reviewed papers in the last 5 years only, out of a total of 78); he acts as reviewer to over twenty scientific journals, several grant funding agencies (NIH, JDRF, and other national and international foundations). A large share of Dr. Galassetti's time is taken up by mentoring activities, These include: a) direct mentoring of UCI residents, fellows, medical and graduate students who participate in Dr. Galassetti's research projects; b) mentoring of junior faculty who are trying to develop independent research lines; c) mentoring of junior investigators involved in clinical-translational projects with other PIs, requesting Dr. Galassetti's expertise; d) mentoring through structured UCI mechanisms, such as the Bio 199 Clinical Research Course, Internships for the UCI Clinical Trial Courses, the UCI Mentored Medical Student Clinical Research Program, the Neonatology Fellows Scholarship Oversight Committee, etc. Many of his trainees co-authored abstracts and papers based on recent study results, and several have won regional and national research awards while under his mentorship. The remaining 25% of the requested salary support will therefore be devoted to the continuation and expansion of these mentoring activities. In summary, Dr. Galassetti is fully committed to a career in Patient Oriented Research. This award will allow to considerably reduce his current onerous amount of administrative and service duties, and proportionally increase protected time dedicated to mentoring and research activities in translational science.