Novel Strategies for Natural Products Synthesis

描述(申请人提供)：这个项目的目标是定义合成二萜生物碱家族中的生物活性分子的新策略和方法。我们构建的复杂分子可以为研究离子通道提供工具，并最终可能被用于开发新的疗法。我们的合成研究也应该有助于更好地理解有机官能团的反应性，因为我们的目标在拥挤的环境中拥有多种官能团。具体地说，我们打算开发策略来合成不同结构类别的二萜生物碱，包括Corriphine，Kobusine和Cossonidine。我们希望我们独特的合成策略和方法能够简化对独特离子通道增强剂的访问。

DESCRIPTION (provided by applicant): The goal of this program is to define new strategies and methods for the synthesis of bioactive molecules in the diterpenoid alkaloid family. The complex molecules that we construct can provide tools to study ion channels and may ultimately be used to develop new therapeutics. Our synthetic studies should also lead to a better understanding of organic functional group reactivity since our targets possess a multitude of functional groups in a congested setting. Specifically, we intend to develop strategies to synthesize different structural classes of diterpenoid alkaloids including coryphine, kobusine and cossonidine. We expect our unique strategies and methods for synthesis to streamline access to unique ion channel potentiators.