Nebraska Center for the Prevention of Obesity Diseases through Dietary Molecules

描述(由申请人提供)：内布拉斯加州-林肯大学与内布拉斯加州大学医学中心合作，提议建立内布拉斯加州通过饮食分子预防肥胖病中心(NPOD)，作为生物医学研究卓越中心。NPOD将联合营养信号方面的研究力量，培养初级教师人才，并利用基于发现的研究和翻译方面的新方法，通过消费者友好和经济高效的干预策略，从关注心血管疾病、糖尿病和非酒精性脂肪性肝病开始，抗击日益流行的肥胖相关疾病。NPOD将创建一个全国认可的中心，负责发展和维持一大批致力于肥胖研究的研究人员，并利用中心的发现来设计和实施有效的战略，通过营养信号通路的饮食操作来预防肥胖相关疾病。中心的目标将通过三个具体目标来实现：(1)建立行政核心和计划，以支持和加强NPOD研究；(2)通过支持五个主题相关的初步研究项目、针对项目负责人的强有力的指导计划、试点赠款计划、分子生物学、生物信息学和生物统计学核心设施以及核心研究工具开发计划，培养足够多的教职员工；以及(3)通过有针对性地招聘对中心成功至关重要的领域的研究人员，提高研究能力。NPOD世界级的多学科研究环境将有助于支持制定预防心血管疾病、糖尿病和非酒精性脂肪性肝病的战略；在国家优先领域建立一支熟练的劳动力队伍；实施将实验室中的发现转化为临床实践和影响消费者行为的技术；以及利用创新方法即时共享研究数据和向消费者传播建议。NPOD研究人员带来了实现该中心宏伟愿景所需的广泛专业知识，并分享了共同的承租人，即肥胖相关疾病可以通过操纵营养信号通路来预防，而且这一预防策略对消费者具有吸引力和可及性，因此具有巨大的长期全国影响潜力。

DESCRIPTION (provided by applicant): The University of Nebraska-Lincoln, in partnership with the University of Nebraska Medical Center, proposes to establish the Nebraska Center for the Prevention of Obesity Diseases through Dietary Molecules (NPOD) as a Center of Biomedical Research Excellence. NPOD will unite research strengths in nutrient signaling to develop junior faculty talent and utilize novel approaches in discovery-based research and translation to combat the growing epidemic of obesity-related disorders through consumer friendly and cost-efficient intervention strategies, beginning with a focus on cardiovascular disease, diabetes, and non-alcoholic fatty liver disease. NPOD will create a nationally recognized center charged with developing and sustaining a critical mass of investigators dedicated to obesity research and leverage Center discoveries to devise and implement effective strategies for the prevention of obesity-related diseases through the dietary manipulation of nutrient signaling pathways. The Center's goals will be accomplished through three specific aims to: (1) establish an administrative core and programs to support and enhance NPOD research; (2) develop a critical mass of faculty through the support of five thematically linked primary research projects, a vigorous mentoring program for Project Leaders, a pilot grant program, a Molecular Biology, Bioinformatics and Biostatistics Core facility, and a research tool development program in the Core; and (3) increase research capacity through targeted recruitment of researchers in areas key to Center success. NPOD's world-class, multidisciplinary research environment will be instrumental in supporting the development of strategies to prevent cardiovascular disease, diabetes, and non-alcoholic fatty liver disease; creating a skilled workforce in a national priority area; implementing techniques fo translating discoveries in the laboratory to inform clinical practice and influence consumer behavior; and utilizing innovative approaches to instant sharing of research data and dissemination of recommendations for consumers. NPOD investigators bring the breadth of expertise necessary to accomplish the Center's grand vision and share the common tenant that obesity-related diseases can be prevented through the manipulation of nutrient signaling pathways and that this prevention strategy is attractive and accessible to consumers, thus holding great potential for long-term national impact.