PILOT AND EXPLORATORY STUDIES CORE

OAIC试点/探索性研究核心的目标是支持未来独立资助研究的规划，这些研究具有很大的潜力，可以促进我们对美国老年人肌肉减少症和身体残疾的潜在机制和预防干预措施的理解。这一目标是通过征集和选择有前途的创新试点和探索性研究来实现的，这些研究涉及OAIC的整体研究主题“肌肉减少症和预防残疾”。 核心通过确保最佳基础设施、环境、资金、专业知识和仪器的可用性来促进试点和探索性研究。核心领导人监督研究进展，协助分析和解释结果，并指导将试验数据转化为高质量和原创性研究 研究成功竞争独立校外资金的提案。为试点和探索性研究提供资金，支持青年学者努力发展老龄化研究事业。该核心还允许在老龄化领域有成就的调查人员收集数据，扩展和拓宽他们的研究领域。 专心点最后，该核心作为一种工具，鼓励和促进传统上在其他研究领域工作的经验丰富的研究人员，如生物力学，生理学或肺病学，以扩大他们对衰老的研究重点。这扩大了人才库，有助于理解和预防肌肉减少症和残疾的进步。我们非常成功地转化了上一个供资周期的试点和探索性研究的结果。在总共19项直接支持或联合支持的试点研究中，13项已通过NIH、VA和基金会获得额外资金;其余6项仍在数据中 收集阶段，或有赠款待定和准备。本申请中提出了一项探索性研究和两项试点研究。由此产生的试点/探索性研究提案组合提供了各种各样的跨学科方法，以解决OAIC的研究主题。

The goal of the OAIC Pilot/Exploratory Studies Core is to support the planning of future independently funded studies with a high potential to advance our understanding of the underlying mechanisms of and preventive interventions for sarcopenia and physical disability in older Americans. This goal is achieved by soliciting and selecting promising innovative pilot and exploratory studies that address the overall OAIC research theme of 'sarcopenia and prevention of disability'. The core fosters pilot and exploratory studies by ensuring the availability of optimal infrastructure, environment, funding, expertise, and instrumentation. The core leaders monitor study progress, assist in the analysis and interpretation of results, and provide guidance in translating pilot data into high quality and original research study proposals that successfully compete for independent extramural funding. The provision of funds for pilot and exploratory studies supports Junior Scholars in their efforts to develop research careers in aging. The core also allows accomplished investigators in the area of aging to gather data which extend and broaden their focus. Finally, the core serves as a vehicle to encourage and facilitate experienced investigators traditionally working in other research fields, such as biomechanics, physiology or pulmonology, to expand their research focus on aging. This broadens the pool of talent contributing to advances in understanding and preventing sarcopenia and disability. We are highly successful in translating findings from our pilot and exploratory studies from the previous funding cycle. Of a total of 19 directly supported or jointly supported pilot studies, 13 have garnered additional funding through NIH, VA and foundation sources; and the remaining 6 are still in the data collection phase, or have grants pending and in preparation. One exploratory and two pilot studies, are proposed in this application. The resultant portfolio of pilot/exploratory study proposals provides a broad variety of interdisciplinary approaches in addressing the OAIC research theme.