Immune suppressor mechanisms in patients with GI cancer

研究表明，肿瘤已经发展出许多逃避肿瘤特异性免疫反应的方法。这些机制最终不仅会促进肿瘤生长，而且会损害基于免疫的癌症治疗的效果。髓系来源的抑制细胞是最近发现的一种细胞群，它在小鼠和人类中都显示出损害肿瘤特异性免疫反应。我们已经能够鉴定出最初仅在小鼠中描述的MDSC的人类对应物，其特征是CD14的表达和低/无水平的HLA-DR。我们已经测试了不同的染色和分离方法，以确定gi道癌症患者中MDSC的相对和绝对频率。目前我们正在研究癌症患者体内MDSC消耗的不同机制。

It has been shown that tumors have developed numerous ways to escape tumor specific immune responses. These mechanisms will ultimately not only enhance tumor growth, but also impair the effect of immune based therapies in cancer. Myeloid derived suppressor cells represent a recently identified cell population, which has been shown to impair tumor specific immune responses both in mice and human. We have been able to identify a human counterpart of the initially only in mice described MDSC, which is characterized by the expression of CD14 and low/no levels of HLA-DR. We have tested different staining and isolation methods to determine relative and absolute MDSC frequencies in patients with cancer of the GI-tract.Currently we are studying different mechanism of how to deplete MDSC in patients with cancer.