Investigation of the role of the GPIb/V/IX-filamin-1 interaction in regulating platelet function in vivo

血小板在凝血和血管修复中起着至关重要的作用。当损伤血管时，血小板迅速附着在损伤区域，在那里它们的形状和内部结构发生巨大变化，这有助于在损伤区域扩散，随后形成稳定的血液凝块。我们的研究旨在更密切地了解调节血小板粘附性的因素，因为这不仅是正常血液凝块形成的重要决定因素，也是与心脏病发作和中风等疾病的发展相关的有害血液凝块(血栓形成)的重要决定因素。我们特别关注的是血小板表面的黏附受体与被称为细胞骨架的细胞内血小板结构成分之间的相互作用，以及这种相互作用如何调节血小板的反应性及其与血管的黏附能力。我们认为这可能是调节血小板黏附和正常凝血的重要机制。

Platelets play an essential role in blood clotting and blod vessel repair. Upon injury to a blood vessel, platelets rapidly adhere to the area of damage where they undergo dramatic changes in their shape and internal structure that facilitates spreading over the area of injury and subsequent formation of a stable blood clot. Our research studies are aimed at understanding more closely the factors that regulate the adhesiveness of platelets, since this is an important determinant not only in normal blood clot formation but also in the development of harmful blood clots (thrombosis) associated with the development of diseases such as heart attack and stroke. Our particular focus is on the interaction between adhesion receptors on the surface of the platelet and components of the intracellular platelet structure referred to as the cytoskeleton and how this interaction might regulate the reactivity of platelets and their ability to adhere to blood vessels. We believe this may be an important mechanism that regulates platelet adhesion and notmal blood clotting.