Barrett's Esophagus Translational Research Network Coordinating Center

巴雷特食道翻译研究网络(BETRNet)已被提出以减少 通过回答关键问题，食管腺癌的发病率、发病率和死亡率 与这种疾病的进展有关的，尤其是在癌前阶段。范德比尔特-英格拉姆 癌症中心BETRNet协调中心(VICC-BETRNetCC)将发挥核心作用 通过实现以下具体目标，促进这些科学进步： 1.确保整个BETRNet的顺利运作，特别是在研究之间的互动方面 中锋。为了实现这一目标，协调中心将提供领导、后勤和行政管理 支持跨网络沟通和互动；建立BETRNet工作组和 小组委员会，提供与BETRNet调查人员需要有关的各个领域的专门知识；以及 促进BETRNet研究中心和NCI之间的沟通。 2.促进跨BETRNet的数据收集、管理、分析和传播。这个 协调中心将提供白银或黄金级别的数据收集和存储基础设施 与caBIG兼容。该中心还将制定机制，确保BETRNet上的机构 随时了解网络中可用的数据和资源，因为这些数据和资源 通过跨学科研究继续发展。此外，协调中心将是 可协助整个研究网络的研究设计和统计分析，特别是 关于高维组学研究，包括最新技术(例如，RNAseq)。 3.开发多机构患者登记系统，以存储临床、纵向和流行病学数据，如 以及可在每个BETRNet站点获得的与生物群落有关的数据集。 4.制定和应用BETRNet的评估指标。这次评估的结果将考虑到中途 更正，以帮助在BETRNet倡议下最大限度地提高研究生产力和效率。

The Barrett's Esophagus Translational Research Network (BETRNet) has been proposed to reduce the incidence, morbidity, and mortality of esophageal adenocarcinoma (EA), through answering key questions related to the progression of this disease, especially in the premalignant stage. The Vanderbilt-lngram Cancer Center BETRNet Coordinating Center (VICC-BETRNetCC) will have a central role to play in facilitating these scientific advances, by achieving the following specific aims: 1. Ensure smooth functioning of the entire BETRNet, especially with regard to interaction among research centers. To achieve this goal, the coordinating center will provide leadership, logistical, and administrative support for cross-network communication and interaction; establish BETRNet working groups and subcommittees to provide expertise in various areas relevant to the needs of BETRNet investigators; and facilitate communication between BETRNet research centers and the NCI. 2. Facilitate data collection, management, analysis, and dissemination across the BETRNet. The coordinating center wiil provide infrastructure for data collection and storage, at the silver or gold level of caBIG compatibility. The center also will develop mechanisms to ensure that institutions across the BETRNet remain informed of the data and resources available within the network, as these data and resources continue to be developed through trans-disciplinary research. Moreover, the coordinating center will be available to assist with study design and statistical analysis across the research network, especially with regard to high-dimensional omics studies, including the latest technologies (e.g., RNAseq). 3. Develop a multi-institutional patient registry to house clinical, longitudinal, and epidemiological data, as well as datasets relevant to biospecimens available at each BETRNet site. 4. Develop and apply evaluation metrics for the BETRNet. Results of this evaluation will allow for mid-course corrections, to help maximize research productivity and efficiency within the BETRNet initiative.