The Female Urinary Microbiome and Urinary Incontinence

 描述（由申请人提供）：我们将确定新发现的女性尿液微生物组的关键特征，即生活在许多成年女性膀胱中的细菌群落，是否与两种常见形式的尿失禁（压力性尿失禁[SUI]和紧迫性尿失禁[UUI]）密切相关。为了进行这项研究，洛约拉研究人员将招募大约1200名妇女（400名来自两个，特征良好的尿失禁队列和400名大陆对照）。他们将确定某些细菌物种或整个微生物组是否与尿失禁症状有关。这些临床亚组之间的显著差异提示尿失禁与女性尿微生物组之间的关系。我们的研究人员拥有各个领域的专业知识，包括专门从事尿失禁护理的临床医生，以及专门从事微生物学和生物信息学的科学家。

 DESCRIPTION (provided by applicant): We will determine whether key characteristics of the newly discovered female urinary microbiome, the bacterial community living in the bladder of many adult women, associate strongly with two common forms of urinary incontinence (stress urinary incontinence [SUI] and urgency urinary incontinence [UUI]). To perform this study, Loyola investigators will recruit approximately 1200 women (400 each from two, well- characterized urinary incontinence cohorts and 400 continent controls). They will determine whether certain bacterial species, or entire microbiomes, are related to urinary incontinence symptoms. A significant difference between these clinical subgroups would be suggestive of a relationship between urinary incontinence and the female urinary microbiome. Our investigators have various areas of expertise including clinicians specializing in urinary incontinence care, and scientists specializing in microbiology and bioinformatics.