Training Program in Cancer Biology

该提案要求继续为我们的癌症生物学培训计划提供资金。我们正在申请继续资助六名博士预科生。2009年，该基金资助了一名系统生物学博士后研究生和4名博士后研究生，并资助了一名系统生物学博士后研究生，这是在上一个供资周期通过对该赠款的补充进行的试点。 该计划已进入第10个年头。该计划集中培训癌症生物学领域的博士前和博士后学员，并提供实验方法的技能，使他们能够成为批判性，创造性和独立的科学家。培训内容不仅包括与癌症发生、发展和转移相关的生物学问题，还包括使用有机化学、纳米技术和系统生物学的跨学科方法，并包括接触癌症诊断和治疗的临床问题。所有教师都在维克森林大学健康科学癌症生物学系担任主要或交叉职务。培训计划的特点包括广泛的指导和评估过程以及职业发展活动。该培训计划通过以下方式实现国家癌症研究所的目标：（1）培养研究人员，使其能够在研究生涯中专注于癌症问题;（2）提供跨越化学和物理生物界面的培训;（3）强调基础科学与癌症患者临床问题之间的联系。 在过去的两个资助周期中，培训计划取得了显著的成功：（1）成功招募了进入并成功完成培训计划的少数民族学员;（2）在癌症研究的新领域进行跨学科培训;（3）申请人的数量和质量，他们的生产力和成就稳步上升。 这项培训计划包括一个完全修订和重新设计的博士后培训计划，以回应最近的批评，并将加强我们的能力，录取高质量的申请人到我们的计划。

This proposal requests continued funding for our Training Program in Cancer Biology. We are requesting continuation of funding for six predoctoral Ph.D. trainees and 4 postdoctoral trainees, as well as funding for one postdoctoral trainee in systems biology, which was piloted in the previous funding cycle through a supplement to this grant. The program is entering its 10th year. The program intensively trains pre- and postdoctoral trainees in the field of cancer biology and provides the skills in experimental approaches so that they can become critical, creative, and independent scientists. Training includes a focus not only on biological relevant issues to cancer initiation, progression and metastases, but also on transdisciplinary approaches using organic chemistry, nanotechnology and systems biology, and includes exposure to clinical issues surrounding cancer diagnosis and treatment. All faculty preceptors have primary or cross appointments in the Department of Cancer Biology of Wake Forest University Health Sciences. Features of the training program include an extensive mentoring and evaluation process and career development activities. This training program addresses the goals of the National Cancer Institute by (1) producing investigators equipped to focus on the cancer problem in their research careers; (2) providing training spanning the chemical- and physical- biological interfaces; (3) emphasizing links between basic science and the clinical problems of patients with cancer. The training program achieved notable successes during the past two funding cycles (1) successful recruitment of minority trainees who entered and successfully completed the training program; (2) cross disciplinary training in new areas of cancer research; (3) a steady rise in the number and quality of applicants, their productivity and their achievements. This training proposal includes an entirely revised and reengineered postdoctoral training program that is responsive to the recent critique and will strengthen our ability to matriculate top quality applicants to our program.