Mount Sinai CHEAR Network Laboratory Hub Targeted Analysis Resource

项目摘要目标资源 目标分析资源是一项多学科全方位服务暴露生物标志物计划，旨在 将环境健康措施纳入美国国立卫生研究院资助的现有研究。我们将与其他人融合在一起 通过完整实验室中心团队的每月执行指导委员会会议广泛提供资源/核心。 其他具体的互动和合作包括从源自 非靶向资源筛选，整合生物响应资源的生物标志物 与我们的靶向暴露生物标记物的潜在毒理学相匹配，并通过帮助开发 核心是产生新的生物标记物，然后实施它们。我们将与行政核心合作 协调服务，包括样品管理、接收、标签和跟踪。我们将担任 与协调中心、PI/客户和其他资源/核心合作的专业顾问 要测量的暴露生物标志物的母体研究目标，研究设计中的因素，人群 年龄、生物标本类型、待研究的表型和分析化学问题。我们将合作 利用数据中心管理结果报告，确保数据格式正确， 拥有足够的元数据，并参与暴露/表型关系的分析。这 资源将使用既定的方法和程序来准备用于分析的样品，并将 制定最先进的实验室间QA/QC程序，以考虑标准问题，如内部 通过使用最先进的实验室信息，不仅可以实现类关联，还可以进行数据库管理 管理软件。这将确保适当的样本跟踪和数据生成/报告，从而避免 样本与结果不匹配。目标资源将维持必要的分析仪器 和设备，以满足CHEAR网络的研究需要并参加年度讲习班 《管理核心》中描述的研讨会计划。QA/QC协议和标准操作程序 对于所有的目标化合物都已建立，以保持化学分析的质量。我们已经 参与金属和有机化学品的几个实验室间比较计划，以验证 分析方法的精密度和准确度，并将在#年进一步开发CHEAR内的新程序 与其他实验室中心合作。总而言之，我们将以高度的 效率和准确性，有助于开发新的方法或新的样本矩阵，提供科学 咨询并与其他中心组件集成工作，同时保持高度的工作效率 和成本效益。

Project Summary Targeted Resource The Targeted Analysis Resource is a multi-disciplinary full service exposure biomarker program designed to integrate environmental health measures into existing NIH funded studies. We will integrate with the other Resources/Cores broadly through monthly Executive Steering Committee meetings of the full Lab Hub team. Other specific interactions and collaborations include identifying new chemicals from the `top hits' derived from the Untargeted Resource screens, integrating the Biological Response Resource's biomarkers of effect to match the underlying toxicology of our targeted exposure biomarkers, and by assisting the Developmental Core in generating new biomarkers and then implementing them. We will work with the Administrative Core to coordinate services, including sample management, receiving, labeling and tracking. We will serve as expertise consultants with the Coordinating Center, PI/Clients and other Resources/Cores to match the goals of the parent study to the exposure biomarkers to be measured, factoring in study design, population age, biological specimen type, phenotypes to be studied and analytical chemistry concerns. We will collaborate with the Data Center in the management of results reporting, ensuring that data are properly formatted and have sufficient metadata, as well as participate in the analysis of exposure/phenotype relationships. This Resource will use established methods and procedures in the preparation of samples for analysis and will develop state of the art inter-laboratory QA/QC procedures which will consider standard issues such as intra- class correlation, but also data base management through our use of state-of-the-art laboratory information management software. This will ensure proper sample tracking and data generation/reporting that avoids mismatches of samples to results. The Targeted Resource will maintain the necessary analytical instruments and equipment to serve the research needs of the CHEAR Network and participate in the Annual Workshop Seminar program described in the Administrative Core. QA/QC protocols and standard operating procedures for all target compounds have been established to maintain the quality of the chemical analysis. We already participate in several inter-laboratory comparison programs for metals and organic chemicals to verify the precision and accuracy of analytical methods and will further develop new programs within CHEAR in conjunction with the other Lab Hubs. In sum, we will process and analyze samples with a high degree of efficiency and accuracy, assist in developing new methods or novel sample matrices, provide scientific consultation and integrate work with the other Hub components while maintaining a high degree of productivity and cost effectiveness.