JHU Center for Neuroscience Research

在这次竞争性更新我们的机构中心核心奖助金以支持神经科学研究时，我们 提议维持和扩大约翰霍普金斯大学现有的三个核心设施的运作 大学医学院(JHU SOM)是在本年度的上一次资助期间建立的 中心格兰特：多光子成像核心、单抗核心和胚胎干细胞 工程核心。这些设施目前提供必要的资源并执行必要的服务 单独的实验室自己提供是不切实际的。这些核心设施的使用将继续 极大地受益于NINDS资助的11个初级中心调查人员的研究计划，以及其他 NINDS资助的JHU SOM调查人员，通过提供独特的设备，培训新的 方法学和新试剂的开发。试验机会和技术服务 由这三个核心提供的补充，但不重复，其他核心设施可供NINS资助 JHU SOM的调查人员。11名小学中心调查人员中有7名是 神经科学系，四名是神经科成员，一名是 病理学系。初级中心研究人员的研究计划尚未解决 神经和神经胶质发育，突触结构和功能，感觉传导， 以及依赖于活性的基因表达调控。初级中心调查人员的具体目标 NINDS资助的研究项目解决了关键的临床问题，包括糖尿病的发育起源 神经功能障碍，损伤或变性后促进神经元再生， 神经病理性疼痛的潜在基础，以及神经退行性疾病(阿尔茨海默病)的起源 和肌萎缩侧索硬化症)。初级中心调查员组成了一个高度互动的小组 有着无缝协作研究的历史。该中心的目标是扩大现有的 通过向这些调查人员以及JHU SOM的其他NINDS资助的调查人员提供研究计划， 拥有这个机构其他地方没有的核心设施。

In this competitive renewal of our Institutional Center Core Grant to support neuroscience research, we propose to maintain and expand the operation of three existing Core facilities at the Johns Hopkins University School of Medicine (JHU SOM) that were established during the previous funding period of this Center Grant: a Multiphoton Imaging Core, a Monoclonal Antibody Core, and an Embryonic Stem Cell Engineering Core. These facilities currently provide necessary resources and perform required services that impractical for individual laboratories to provide on their own. Use of these Core facilities will continue to greatly benefit NINDS-funded research programs of the eleven Primary Center Investigators, and also other NINDS-funded investigators at JHU SOM, by providing access to unique equipment, training in new methodologies, and development of new reagents. The experimental opportunities and technical services offered by these three Cores complement, but do not duplicate, other Core facilities available to NINDSfunded investigators at JHU SOM. Seven of the eleven Primary Center Investigators are members of the Department of Neuroscience, four are members of the Department of Neurology,a nd one is in the Department of Pathology. The research programs of the Primary Center Investigators address unresolved issues in the areas of neural and glial development, synaptic structure and function, sensory transduction, and activity-dependent regulation of gene expression. The Specific Aims of Primary Center Investigators' NINDS-funded research programs address critical clinical issues, including the developmental origins of neurological disorders, the promotion of neuronal regeneration following injury or degeneration, the underlying basis of neuropathic pain, and the origin of neurodegenerative disorders (Alzheimer's Dementia and Amyotrophic Lateral Sclerosis). The Primary Center Investigators constitute a highly interactive group with a history of seamless collaborative research efforts. The goal of this Center is to augment existing research programs by providing these investigators, and other NINDS-funded investigators at JHU SOM, with Core facilities that are not available elsewhere at this institution.