University of Florida Claude D. Pepper Older Americans Independence Center (OAIC)

项目总结 佛罗里达大学老年美国人独立中心(OAIC)的使命有两个：1)优化 通过跨学科方法提高老年人的身体表现和行动能力；和2)培训新的 研究人员在衰老和残疾研究的同时发展他们的领导素质。我们的目标是增强 晚年健康和独立，特别注重行动能力。为了完成我们的使命，我们的战略是 吸引来自不同行为科学、临床科学、基础科学和技术科学的研究和创造性研究人员 具有共同研究重点的学科：“行动能力和残疾预防”。遍历整个光谱 生物医学研究，包括分子生物学、动物研究、临床研究、行为科学、 流行病学和工程学，我们的研究努力满足了OAIC的总体目标：增加科学研究 导致更好地保持或恢复老年人独立性的知识。我们的研究目标 是：1)使用转译研究(在不同学科之间)评估生物学、共病、 心理社会、行为和其他因素，导致身体功能下降、行动不便和 进展为残疾；以及2)在临床和临床前研究中开发并可靠地测试干预措施，以 以行动能力为目标，防止、延缓或恢复与年龄相关的身体机能下降。我们的教育目标 是培养未来衰老临床转化性研究的领导者。为达致这些目标，拟议的组织及执行委员会 培训初级学者，支持研究人员、资源、服务、外部研究、开发项目、 以及通过七个综合核心进行的试点/探索性研究： ·领导力和行政核心； ·研究教育核心； ·试点/探索性研究核心； ·临床研究核心； ·新陈代谢和翻译科学核心； ·生物统计核心；以及 ·数据科学和应用技术核心。 拟议的OAIC的一个相关优势是跨学科核心、项目和 研究人员解决了跨越整个生物医学调查范围的一个共同的研究重点。

PROJECT SUMMARY The mission of the University of Florida Older Americans Independence Center (OAIC) is twofold: 1) to optimize older persons' physical performance and mobility through interdisciplinary approaches; and 2) to train new investigators in aging and disability research while developing their leadership qualities. Our goal is to enhance late-life health and independence, with a special focus on mobility. To accomplish our mission, our strategy is to attract studies and inventive investigators from diverse behavioral, clinical, basic, and technological science disciplines with a common research focus: “mobility and prevention of disability.” Traversing the entire spectrum of biomedical investigation, including molecular biology, animal studies, clinical research, behavioral sciences, epidemiology, and engineering, our research effort addresses the OAIC's general goal: to increase scientific knowledge that leads to better ways to maintain or restore independence of older people. Our research objectives are to: 1) assess, using translational research (among diverse disciplines), the biological, co-morbid, psychosocial, behavioral, and other factors that contribute to physical function decline, loss of mobility, and progression toward disability; and 2) develop and reliably test, in clinical and preclinical studies, interventions that target mobility to prevent, delay, or recover the age-related declines in physical function. Our educational objective is to train future leaders in clinical translational research on aging. To meet these objectives the proposed OAIC trains Junior Scholars and supports investigators, resources, services, external studies, development projects, and pilot/exploratory studies through seven integrated cores: • Leadership and Administrative Core; • Research Education Core; • Pilot/Exploratory Studies Core; • Clinical Research Core; • Metabolism and Translational Science Core; • Biostatistics Core; and • Data Science and Applied Technology Core. A relevant strength of the proposed OAIC is the concerted action of the interdisciplinary cores, projects, and investigators who address one common research focus spanning the entire spectrum of biomedical investigation.