Global Cardiometabolic Disease Training

 描述(由申请人提供)：我们建议一个全球心脏代谢性疾病(GCMD)博士前培训计划。这一以营养为重点的跨学科计划将提供专门培训，培养一支能够连接基础生物科学研究和基于人群的研究的研究队伍，以减少全球心脏代谢性疾病发病率和死亡率方面日益增长的负担和差距。虽然人们越来越多地认识到心脏代谢性疾病的高患病率、高负担和上升趋势，特别是在低收入和中等收入国家，但在解决这一重要问题方面所做的工作很少。该培训计划将在营养系内管理，该系设在吉林斯全球公共卫生学院和北卡罗来纳大学医学院，使其成为获得GCMD培训补助金的合乎逻辑和地理位置优越的地方。营养研究整合了遗传学、表观遗传学、生化、行为和流行病学数据，以了解饮食、慢性病和肥胖之间的复杂相互作用，从而为培养该领域的翻译全球科学研究人员提供了强大的平台。我们的节目将由 两名资深教员，在心脏代谢性疾病相关研究方面拥有强大的指导记录和广泛的全球经验和领导能力。该计划将由一个内部培训委员会和一个外部顾问委员会指导。我们的培训人员包括21名资深和初级科学家，他们在广泛的学科领域拥有大量的研究支持和出版记录。我们要求每年为五名博士前实习生提供支持。学员将在系的三个部门(生物化学、流行病学或干预和政策)中的一个完成博士学位，此外，学员将完成GCMD培训补助金的特定要求，包括全球健康和心脏代谢疾病、实施科学/转化医学、由项目主任主持的研讨会、有指导的研究实践、负责任的研究行为培训、职业发展指导和全球实习，为学生提供直接接触美国以外心脏代谢疾病研究的环境。我们的培训计划之所以脱颖而出，是因为它：(1)专注于营养，这是全球疾病负担的主要病因；(2)解决非传染性疾病的生命过程方法；(3)跨学科关注从细胞和分子到整个生物体的原因，并考虑潜在的社会、经济、政治和环境决定因素；(4)强调将营养生物化学、生理学、遗传学和流行病学的基本知识和发现整合和转化为行为和环境方法和政策；以及(5)杰出的教师导师，他们是全球心脏代谢性疾病研究中卓越的榜样，以及与各国合作实施和评估预防心脏代谢性疾病的大规模监管努力的领导人。GCMD培训计划将为全球心脏代谢性疾病研究培养未来的领导者。

 DESCRIPTION (provided by applicant): We propose a global cardiometabolic disease (GCMD) pre-doctoral training program. This interdisciplinary nutrition-focused program will provide specialized training to develop a cadre of researchers who can bridge basic biological science research and population-based studies to reduce the growing burden and disparities in global cardiometabolic disease morbidity and mortality. While there is increasing recognition of the high prevalence, burden, and upward trends in cardiometabolic disease, particularly in low and middle income countries, little has been done to address this important problem. The training program will be administered within the Department of Nutrition, which is housed within the Gillings School of Global Public Health and the UNC School of Medicine, making it a logical and well-placed home for a GCMD training grant. Nutrition research integrates genetic, epigenetic, biochemical, behavioral, and epidemiological data to understand the complex interactions between diet, chronic disease and obesity, thus providing a strong platform for training translational global science researchers in this field. Our program will be co-directed by two senior faculty members with strong mentoring records and extensive global experience and leadership in cardiometabolic disease-related research. The program will be guided by an internal training committee and an external advisory board. Our training faculty includes 21 senior and junior scientists with substantial research support and publication records across a wide range of disciplines. We request support for five pre-doctoral trainees per year. Trainees will complete the PhD in one of the department's three divisions (biochemistry, epidemiology, or intervention and policy) and in addition, trainees will complete GCMD training grant-specific requirements that include specialized courses in global health and cardiometabolic disease, implementation science/translational medicine, a seminar led by the program directors, mentored research practicums, training in the responsible conduct of research, mentoring for professional development and a global internship in a setting that will provide the student with direct exposure to cardiometabolic disease research outside of the US. Our training program stands out because of its: (1) focus on nutrition, a major etiologic factor in the global disease burden; (2) life course approach to addressing non-communicable diseases; (3) interdisciplinary focus on causes ranging from cellular and molecular to whole organism and accounting for underlying social, economic, political, and environmental determinants; (4) emphasis on integration and translation of basic knowledge and discoveries from nutrition biochemistry, physiology, genetics, and epidemiology, to behavioral and environmental approaches and policies; and (5) outstanding faculty mentors who serve as role models for excellence in global cardiometabolic disease research and leaders working with countries to implement and evaluate large-scale regulatory efforts to prevent cardiometabolic disease. The GCMD training program will train future leaders for careers in global cardiometabolic disease research.