HERCULES: Exposome Research Center

项目总结：大力神 Hercules P30的愿景是明显推动环境健康科学在 临床和公共卫生设置使用的平台的曝光组。医疗保健和生物医学研究 变得越来越以基因组为中心。虽然这在很大程度上要归功于基因组学令人印象深刻的成就， 我们认为，一个更有说服力的案例 需要考虑环境因素。科学和直觉支持这样一种观点，即环境在 在大多数疾病中，基因的作用与基因一样重要。介绍，其中包含了一种战略和 类似于基因组研究的规模，正准备在关于健康和疾病的讨论中提升环境。 我们将通过以下途径继续发展和加强埃默里的环境健康科学研究项目 尖端技术和创新的数据解决方案。我们将在我们拥有的卓越关系的基础上再接再厉 与当地社区共同建设，继续推动NIEHS在校园和整个科学领域的使命 风景。基于我们头三年取得的非凡进展，我们建议保留我们的主题 使用与曝光组相关的概念和方法来改善人类健康。这一简单而统一的愿景将 继续通过以下方式促进发现、促进协作和加强沟通 具体目标：具体目标1.调集体力和智力资源支持与曝光有关的工作 方法(高分辨率代谢组学、分析化学、系统生物学、机器学习、 生物信息学、高通量毒理学以及空间和时间统计模型) 资助、指导和研究论坛。具体目标2.为曝光和宣传作出重大贡献 环境健康科学研究。具体目标3.围绕以下方面提供职业发展活动 与展示会有关的创新和新兴概念和方法。具体目标4.加强和加强 扩大与社区合作伙伴的现有关系，以解决社区的环境健康问题 使用暴露的原则。具体目标5.提供基础设施和资源，以促进快速翻译 将新的科学发现应用于人类预防和治疗策略的开发。追求 大力神的目标将推动我们机构内的环境健康科学和科学 社区。

PROJECT SUMMARY: HERCULES The vision of the HERCULES P30 is to demonstrably advance the role of environmental health sciences in clinical and public health settings using the platform of the exposome. Healthcare and biomedical research have become increasingly genome-centric. While much of this is due to the impressive achievements in genomics, which have consistently outpaced gains in environmental health, it is our contention that a more persuasive case needs to be made for environmental factors. Science and intuition support the idea that the environment plays just as large of a role as genetics for the majority of diseases. The exposome, which embraces a strategy and scale similar to genomic research, is poised to elevate the environment in discussions of health and disease. We will continue to grow and enhance the environmental health science research portfolio at Emory through cutting-edge technologies and innovative data solutions. We will build upon the superb relationships we have built with the local community and continue to push the mission of NIEHS on campus and across the scientific landscape. Based on the extraordinary progress over our first three years, we propose to retain our theme to use exposome-related concepts and approaches to improve human health. This simple and unifying vision will continue to stimulate discovery, promote collaboration, and enhance communication through the following Specific Aims: Specific Aim 1. To marshal physical and intellectual resources to support exposome-related approaches (high-resolution metabolomics, analytical chemistry, systems biology, machine learning, bioinformatics, high-throughput toxicology, and spatial and temporal statistical models) through cores, pilot funding, mentoring, and research forums. Specific Aim 2. To make major contributions towards exposome and environmental health science research. Specific Aim 3. To provide career development activities around innovative and emerging concepts and approaches related to the exposome. Specific Aim 4. To enhance and expand existing relationships with community partners to resolve environmental health issues in the community using exposome principles. Specific Aim 5. To provide infrastructure and resources to facilitate rapid translation of novel scientific findings into the development of prevention and treatment strategies in humans. Pursuit of HERCULES' aims will advance environmental health sciences within our institutions and in the scientific community.