Postdoctoral Training Program in Genomic Medicine

基因组学技术已经足够先进，可以测量细胞中的DNA序列变异和RNA表达。 临床样本。然而，将基因组测量整合到医疗保健中的速度超过了培训 许多医生和科学家没有能力利用这些信息来改善病人的健康。 因此，培养下一代基因组医学的医生和科学家领导者势在必行。在 宾夕法尼亚大学，我们提出了一个基因组医学博士后培训计划，重点是 转化医学和信息学，将由Jason摩尔博士，爱德华罗斯信息学教授， 和宾夕法尼亚大学生物医学信息学研究所所长，以及医学教授凯瑟琳内桑森 艾布拉姆森癌症中心人口科学副主任。这是一个挑战 该计划提供了基因组医学培训的基础，适用于医学博士和博士培训 研究员，认识到每个人都可能以不同的技能和经验进入该计划。因此 必须为所有研究员提供一个强大的背景框架，使他们能够发展令人兴奋的， 基因组医学的相关项目。学员将参加一个为期两年的计划，包括教学 课程，临床和实验室轮换，互动学习经验和研究培训。我们要求 一个平衡的课程组合，将涵盖基因组学的最新进展，重点是 疾病过程中的基因组学，定量科学，包括生物医学信息学和生物统计学， 科学写作和ELSI问题。32名培训师是根据他们在基因组学方面的专业知识挑选出来的。 医学和来自多个部门，这是进一步扩大与临床经验， 提供基因组医学。学员将在一个研究项目中由一个平衡的团队进行双重指导 (e.g.临床医生和基础科学家）在基因组医学方面经验丰富。学员将参加临床 旋转设计，让他们的经验，从大规模并行序列的产生， 从数据到数据分析，再到向患者报告结果。学员还将参加互动 活动，其中包括期刊俱乐部，研究进展介绍，临床遗传学回合， 撤退。这种课程作业、体验式临床轮转、参与互动活动的结合， 和指导的研究经验将准备我们的医生和科学家在基因组医学的职业生涯。 宾夕法尼亚大学的申请人群体非常强大和多样化，我们预计 能够吸引优秀人才。我们计划在头两年每年招收两名学员， 三是在后三年。

Genomics technology is sufficiently advanced to measure DNA sequence variation and RNA expression in clinical samples. However, the integration of genomic measurements into healthcare is outpacing the training of physicians and scientists, and many are ill-equipped to use this information to improve the health of patients. Thus, it is imperative to train the next generation of physician and scientist leaders in Genomic Medicine. At the University of Pennsylvania, we propose a post-doctoral training program in Genomic Medicine, focused on translational medicine and informatics, to be led by Drs. Jason Moore, Edward Rose Professor of Informatics, and Director of the Penn Institute for Biomedical Informatics, and Katherine Nathanson, Professor of Medicine and Genetics, and Associate Director of Population Sciences, Abramson Cancer Center. A challenge for this program is providing a foundation for training in Genomic Medicine, applicable to both MD and PhD trained fellows, recognizing that each may enter the program with different skill sets and experiences. It is thus essential to provide all fellows with a strong background framework so that they can develop exciting and relevant projects in Genomic Medicine. The trainees will enroll in a two year program, including didactic courses, clinical and laboratories rotations, interactive learning experiences and research training. We require a balanced portfolio of courses, which will cover the latest advances in genomics, focused on the role of genomics in disease processes, quantitative sciences, including biomedical informatics and biostatistics, scientific writing and ELSI issues. The 32 trainers have been selected based on their expertise in Genomic Medicine and come from multiple departments, which is further enlarged with clinicians experience in the provision of Genomic Medicine. The trainees will be dually mentored in a research project by a balanced team (e.g. clinician and basic scientist) experienced in Genomic Medicine. Trainees will participate in clinical rotations designed to give them experiences that range from the generation of massively parallel sequence data to data analysis to reporting back the results to patients. Trainees also will participate in interactive activities, which include a journal club, research in progress presentations, clinical genetics rounds and retreats. This combination of coursework, experiential clinical rotations, participation in interactive activities, and mentored research experience will prepare our physicians and scientists for careers in Genomic Medicine. The applicant pool at the University of Pennsylvania is exceptionally strong and diverse, and we anticipate being able to attract outstanding candidates. We plan to enroll two trainees per year for the first two years, and three in the latter three years.