Functional Analysis of Sleep Promoting Neurons in Health and Disease

睡眠、选择性注意力和记忆巩固会受到许多负面影响，如果没有的话 大多数是神经系统疾病。有趣的是，最近的研究表明，神经元活动 清醒时可能会改变罹患阿尔茨海默氏症的风险。考虑到这一点，我们 已经发现了一种受阿尔茨海默病影响的基因易受影响的神经回路 它还特别适合于剖析动态的双向关系 睡眠和认知。也就是说，我们对定义一个最小的神经元集合不太感兴趣 控制行为比我们理解这些神经元如何相互作用更重要(例如，通过睡眠- 认知连接体)。在这项提案中，我们将研究如何在飞行中连接结构 大脑共同调节睡眠和认知在健康期间和在 阿尔茨海默氏症。因为我们最近证明了睡眠的力量可以 被用来逆转阿尔茨海默病果蝇模型的认知障碍 本提案的目标将是定义电路的功能属性，以赋予 睡眠对认知过程的好处。

Sleep, selective-attention and memory consolidation are adversely impacted by many, if not most, neurological conditions. Interestingly, recent studies suggest that neuronal activity during waking may alter the risk for developing Alzheimer's disease. With this in mind, we have identified a genetically-tractable neural circuit that is impacted by Alzheimer's disease and is also uniquely suited for dissecting the dynamic, bi-directional relationship between sleep and cognition. That is, we are less interested in defining a minimal set of neurons that control a behavior than we are in understanding how these neurons interact (e.g., via a sleep- cognitive connectome). In this proposal we will investigate how connected structures in the fly brain work together to regulate sleep and cognition during health and in the context of Alzheimer's disease. Since we have recently demonstrated that the power of sleep can be harnessed to reverse cognitive impairments in a Drosophila model of Alzheimer's disease, a goal of this proposal will be to define the functional properties of circuits that confer the benefits of sleep to cognitive processes.