Optimized Measurement and Signal Processing of Fetal MCG

摘要 胎儿心脏电生理学的无创评估还没有常规可能， 数十年的胎儿心电图研究。然而，最近，我们和其他小组已经证明了 胎儿心磁图（fMCG）是胎儿心电图的磁性模拟物，作为一种有效的新方法， 评估胎儿心率、节律和传导。 该计划的长期目标是将快速消费品开发为胎儿检查的新技术， 临床应用。如果成功的话，这项研究可以提高对危及生命的胎儿畸形的诊断。 心律失常和阐明原因不明的胎儿死亡。 在过去的几年里，在证明快速消费品的诊断功效方面取得了显着进展。 快速消费品技术的发展也取得了重要进展。在下一个项目中 在此期间，我们将重点关注几个领域，这些领域对于克服快速消费品临床应用的障碍至关重要。 FMCG仍然是一个非常新的领域。需要更多的人类研究来更好地定义和进一步扩展 fMCG在胎儿长QT综合征和其他危及生命的胎儿心律失常的临床管理中的作用 光泵磁力计（OPMs）是一项重要的突破，可以克服一个主要的 通过使该技术更加实用和具有成本效益，消除了快速消费品临床采用的障碍。具体 目标如下： 1.对有LQTS风险的胎儿进行系列研究。对LQTS的发展知之甚少 在出生之前。这些研究需要确定早期症状是如何表现的， 疾病的进展，并帮助确定频率和时间的快速消费品会议， 胎儿LQTS的最佳临床管理。 2.继续我们对妊娠合并胎儿心律失常和其他高危妊娠的研究 条件拟议的研究将有助于确定快速消费品对临床管理的贡献 一系列严重的胎儿心律失常，包括一些以前没有研究过。 3.展示OPM作为快速消费品新技术的有效性。我们将直接比较 使用OPM系统和FDA批准的SQUID磁力计进行记录。

ABSTRACT Noninvasive assessment of fetal cardiac electrophysiology has not been routinely possible despite many decades of fetal ECG research. Recently, however, we and other groups have demonstrated the utility of fetal magnetocardiography (fMCG), the magnetic analog of fetal ECG, as an effective new method of assessing fetal heart rate, rhythm, and conduction. The long-term goal of this program is to develop fMCG as a new technology for fetal investigation and clinical application. If successful, the research can improve the diagnosis of life-threatening forms of fetal arrhythmia and shed light on causes of unexplained fetal death. The last few years have seen remarkable progress in demonstrating the diagnostic efficacy of fMCG. Crucial progress has also been made toward the development of fMCG technology. During the next project period, we will focus on several areas that are critical to overcoming the obstacles to clinical adoption of fMCG. FMCG is still a very new area. Additional human studies are needed to better define and further expand the role of fMCG for clinical management of fetal long QT syndrome and other life-threatening fetal arrhythmia. Optically-pumped magnetometers (OPMs) represent an important breakthrough that can overcome a major barrier to clinical adoption of fMCG by making the technique more practical and cost-effective. The specific aims are as follows: 1. Perform serial studies of fetuses at risk of LQTS. Little is known about the development of LQTS prior to birth. The studies are needed to ascertain how early symptoms manifest, follow the progression of the disease, and help determine the frequency and timing of fMCG sessions for optimal clinical management of fetal LQTS. 2. Continue our studies of pregnancies complicated by fetal arrhythmia and other high-risk pregnancy conditions. The proposed studies will help define the contribution of fMCG for clinical management of a range of serious fetal arrhythmia, including some that have not been previously studied. 3. Demonstrate the efficacy of OPMs as a new technology for fMCG. We will directly compare recordings made with an OPM system and an FDA-cleared SQUID magnetometer.