Oncopathology Training Program

项目总结 这是Ruth L.Kirschstein国家研究服务奖机构研究的新申请 培训补助金(T32)，用于培训肿瘤病理学领域的博士后实习生，广义上定义为研究 它旨在提高我们对癌症发病机制和病理生物学的理解，并在这样做的过程中提供 为改进癌症诊断、预后和治疗的新方法的开发奠定基础。 肿瘤病理学培训计划(OTP)的总体目标是提供研究培训机会 跨越肿瘤病理学研究的全范围，从使用工具的癌症发病机制的基础研究 细胞和分子生物学、基因组学、蛋白质组学、动物建模和生物信息学，到翻译 涉及开发和部署生物标记物测试以及使用数字和 计算病理学，在癌症研究中日益重要的方法。培训计划 旨在帮助医学博士和医学博士/博士实习生在毕业后的研究生涯发展 临床和/或解剖病理学培训，以及具有以下教育背景的博士生 对计算病理学这一新兴领域感兴趣的计算领域。请求为%4提供支持 博士后培训在1-2年级，5名学员在3-5年级。培训计划包括结构化的 个人发展计划、有指导的研究经验和可定制的教学内容等要素 培训机会以及资助撰写、手稿撰写和实验室管理方面的研讨会。 每个受训人员将有博士后咨询委员会，由项目主任，初级研究 导师，以及一名或多名具有相关专业知识的资深癌症研究人员，他们将审查学员的进展， 提供建议和建设性的批评，并作为外部奖学金提案的审查委员会。 OTP的教职员工包括24名非常有成就的调查人员，他们有广泛的指导记录和 大量的校外赠款支持，他们构成了一个高度合作的指导社区，其 专业知识横跨广泛的多学科、肿瘤病理学相关领域，包括 癌症，癌症免疫学，癌症基因组学，计算病理学和组织成像，癌症 诊断学和癌症翻译信息学。OTP还将利用广泛的 布里格姆妇女医院提供的科学和教育资源的补充 (BWH)，哈佛医学院(HMS)。和Dana Farber癌症研究所(DFCI)，包括NCI资助的 达纳-法伯/哈佛癌症中心。

PROJECT SUMMARY This is a new application for a Ruth L. Kirschstein National Research Service Award Institutional Research Training Grant (T32) to train post-doctoral trainees in the field of oncopathology, defined broadly as research that seeks to improve our understanding of cancer pathogenesis and pathobiology, and in doing so provide the basis for the development of new approaches that improve cancer diagnosis, prognostication, and treatment. The overall goal of the Oncopathology Training Program (OTP) is to provide research training opportunities across the full spectrum of oncopathology research, from basic study of cancer pathogenesis using the tools of cell and molecular biology, genomics, proteomics, animal modeling, and bioinformatics, to translational research that involves the development and deployment of biomarker tests and the use of digital and computational pathology, approaches that are increasingly important in cancer research. The training program is designed to benefit the research career development of M.D. and M.D./Ph.D. trainees subsequent to their training in clinical and/or anatomic pathology, and Ph.D. trainees with educational backgrounds in computational fields interested in the emerging area of computational pathology. Support is requested for 4 postdoctoral trainees in years 1-2, and 5 trainees in years 3-5. The training program includes structured elements such as individual development plans, mentored research experiences, and customizable didactic training opportunities as well as workshops in grant writing, manuscript composition, and lab management. Each trainee will have Postdoctoral Advisory Committee comprised of the Program Director, primary research mentor, and one or more senior cancer researchers with relevant expertise that will review trainee progress, provide advice and constructive criticism, and serve as a review committee for external fellowship proposals. The OTP faculty includes 24 highly accomplished investigators, with extensive mentoring track records and substantial extramural grant support, who constitute a highly collaborative mentoring community whose expertise span a wide-range of multidisciplinary, oncopathology-relevant areas, including animal modeling of cancer, cancer immunology, cancer genomics, computational pathology and tissue imaging, cancer diagnostics, and translational cancer informatics. The OTP will also take advantage of the extensive complement of scientific and educational resources that are available at Brigham and Women’s Hospital (BWH), Harvard Medical School (HMS). and Dana Farber Cancer Institute (DFCI), including the NCI-funded Dana-Farber/Harvard Cancer Center.