VGM: Vanderbilt Genomic Medicine Training Program

项目总结 本申请旨在续订范德比尔特大学的范德比尔特基因组医学(VGM)培训计划 大学医学中心(VUMC)。VGM研究员接受过数据科学、生物信息学、实验室等方面的培训 科学和基因组发现；该计划还指导研究员的基因组医学实践。VGM 在VUMC的关键支持资源和基础设施方面建立了数十年的优势，包括：1) BioVU，将DNA样本链接到电子病历(EMR)的最大生物库 机构(现为244,000名受试者)，2)参与由NHGRI资助的三个网络：电子医疗 记录和基因组学(Emerge)网络和Emerge协调中心，在 实践(INIGITE)网络和未诊断疾病网络(UDN)，3)药物基因组学 增强护理和治疗决策的资源(预测)项目，嵌入 电子健康记录(EHR)中的药物基因组测试以指导药物和剂量选择4)a 应用肿瘤基因组测序来识别癌症中可操作的突变的精确肿瘤学计划 和个性化靶向治疗，以及6)全国最大的生物医学信息学系，拥有 在临床信息技术方面有强大的研究、教育和支持计划。该计划有35个 高度协作和资金充足的教员导师，他们合作提供基础和临床研究 获得博士和医学博士级别的博士后研究员的机会。学员将参加轮换、研讨会、 杂志俱乐部，以及静修和与其他临床和研究研究员和教职员工互动。在范德比尔特的 生物医学研究教育和培训(BRET)办公室，该计划将在 研究(RCR)培训、高标准个人发展计划(IDP)和职业发展 项目的目标是将研究员培养成下一代基因组医学的领导者。一个科学的人 咨询委员会和外部咨询委员会就VGM计划提供宝贵的建议 发展和增强。该计划积极从不同人群中寻找候选人，并 具有专业和研究背景。我们的基本模式是加强多学科培训 通过根据以前的经验为每个学员量身定做的课程，再加上配对的指导 提供临床和方法学方面的专业知识。

PROJECT SUMMARY This application seeks to renew the Vanderbilt Genomic Medicine (VGM) training program at Vanderbilt University Medical Center (VUMC). VGM fellows are trained in data science, bioinformatics, laboratory science, and genomic discovery; the program also instructs fellows on the practice of genomic medicine. VGM builds on decades-long strengths in critical enabling resources and infrastructure within VUMC including: 1) BioVU, the largest biobank linking DNA samples to electronic medical records (EMRs) at a single academic institution (now >244,000 subjects), 2) Participation in three NHGRI-funded networks: the Electronic Medical Records and Genomics (eMERGE) network and eMERGE coordinating center, the Implementing Genomics in Practice (IGNITE) Network, and the Undiagnosed Disease Network (UDN), 3) The Pharmacogenomic Resource for Enhanced Decisions In Care and Treatment (PREDICT) project which embeds pharmacogenomic testing within electronic health records (EHRs) to guide drug and dosage choices 4) a Precision Oncology program that applies tumor genome sequencing to identify actionable mutations in cancers and to personalized target therapy, and 6) the largest Department of Biomedical Informatics in the country, with strong research, education, and support programs in clinical information technology. The program has 35 highly collaborative and well-funded faculty preceptors who team up to provide both basic and clinical research opportunities to Ph.D.-level and M.D.-level postdoctoral fellows. Trainees will participate in rotations, seminars, journal clubs, and retreats and interact with other clinical and research fellows and faculty. Under Vanderbilt’s Biomedical Research Education and Training (BRET) Office, the program will provide Responsible Conduct in Research (RCR) training, high-standard Individual Development Plans (IDP), and Career Development programs with the goal of developing fellows to be next-generation leaders in genomic medicine. A Scientific Advisory Committee and an External Advisory Committee provide valuable advice on VGM program development and enhancement. The program actively seeks candidates from diverse populations and professional and research backgrounds. Our fundamental model is to enhance multidisciplinary training through a curriculum tailored for each trainee based on prior experience, coupled to paired mentoring to provide both clinical and methodological expertise.