Core B: Human subjects

项目摘要/摘要--核心B 临床研究中心由核心B(人类受试者)支持。核心B(目标B.1)是 负责招募代表当地人口的男性和女性受试者 社区参与(1)年龄相关性听力损失的纵向研究，(2)建议的实验 在项目3和项目4中，(3)为项目1中建议的实验捐赠DNA，以及(4)捐赠 项目1和项目2中提出的用于实验的人类颞骨。核心B(目标B.2)管理 收集、存储和分析人口统计、听力和生物/医学数据和组织(血液和 来自人类受试者的DNA)。这些数据定义了每个受试者的基本听力特征，并补充了 可能与此配置文件相关联的度量，并组织到可搜索的数据库中，该数据库 提供根据每个科学家的注册标准招募受试者所需的关键信息 项目。与目标B.1一起，目标是确保科学项目招收所需数量的 具有不同听力特征的受试者，获得所需数量的DNA样本，并获得足够的 人类颞骨的数量。核心B(目标B.3)协调人类主体的主体时间表 方案(纵向措施和年度评估)、耳鼻咽喉科诊所就诊和实验室就诊 为临床化验和DNA抽血。由于项目之间的紧密联系，有大量的 主体参与需求的重叠。因此，核心B有效地利用了受试者的测试时间和 协调他们的数据存储，以优化科学项目的数据访问和分析。

PROJECT SUMMARY/ABSTRACT – CORE B The Clinical Research Center is supported by Core B (Human Subjects). Core B (Aim B.1) is responsible for recruitment of female and male human subjects representing the population of the local community for participation in (1) the longitudinal study of age-related hearing loss, (2) experiments proposed in Project 3 and Project 4, (3) donation of DNA for experiments proposed in Project 1, and (4) donation of human temporal bones for experiments proposed in Project 1 and Project 2. Core B (Aim B.2) manages the collection, storage, and analysis of demographic, audiologic, and biologic/medical data and tissue (blood and DNA) from human subjects. These data define the basic audiologic profile of each subject, supplemented by measures that may be associated with this profile, and are organized into a searchable database, which provides key information needed to recruit subjects according to the enrollment criteria for each scientific project. Together with Aim B.1, the goal is to ensure the scientific projects enroll the required numbers of subjects with various audiologic profiles, obtain the required numbers of DNA samples, and acquire sufficient numbers of human temporal bones. Core B (Aim B.3) coordinates subject schedules for the human subject protocol (longitudinal measures and annual evaluations), Otolaryngology clinic visits, and laboratory visits for blood draws for clinical chemistries and DNA. Because of the strong links among projects, there is substantial overlap of needs for subject participation. Thus, Core B makes efficient use of subjects' testing time and coordinates storage of their data to optimize data access and analyses for the scientific projects.