Molecular Transducers of Physical Activity Consortium (MoTrPAC): Pediatric Clinical Center

项目总结 体力活动联盟的分子传感器(MoTrPAC)旨在发现和表征 运动对人体产生影响的分子传感器的范围。MoTrPAC是在 2016年，有六个成人临床中心和一个儿科中心合作编写了广泛的手册 指导涉及临床手术所有方面的研究方案(第一阶段)。第二阶段 开始于2019年秋季，所有人类临床中心在初步招聘方面取得了出色的进展 议定书的目标和实施。美国国立卫生研究院最初设定的目标是招募270名儿童(10-17岁 年)和1980年久坐不动的成年人(18岁或以上)随机接受耐力训练 (170名青年，840名成人)，阻力训练(840名成人)，或非运动对照组(50名青年，300名成人)。一个 另外一组高度活跃的耐力(50名青年，150名成人)和抵抗(150名成人)训练有素的个人 作为参照者，不参加MoTrPAC运动训练计划。招聘和 招生方法是性别均衡的，参与者的年龄范围很广(10-17岁、18-39岁、40-59岁 和60岁年龄组)和不同种族。由于新冠肺炎大流行，MoTrPAC的活动 暂停一年多(从2020年3月开始)，到2022年继续受到限制。尽管 由于大流行而遇到的许多挑战，成人和儿科的招募活动 临床中心已加快速度，预计将成功实现目标登记人数 在新的奖励期结束之前。这导致NIH共同基金发布了目前的NOFO(RFA-RM- 23-010)向MoTrPAC提供资金，以完成临床研究的招募和后续工作，包括 久坐不动的成人和儿童的机制随机对照试验和观察性研究 高度活跃的成年人和儿童。这将丰富对了解锻炼至关重要的参与者队列 不同年龄、性别和少数群体的适应性和异质性。总而言之，这一延期将允许 MoTrPAC完成了最初设想的预期目标，并将提供更完整的公众 运动对健康有益的数据库，并提供对体育活动如何减轻疾病的洞察。

PROJECT SUMMARY The Molecular Transducers of Physical Activity Consortium (MoTrPAC) is designed to discover and characterize the range of molecular transducers that underlie the effects of exercise in humans. MoTrPAC was launched in 2016 with six adult clinical centers and a pediatric center that have collaborated to generate extensive Manual of Operations to guide research protocols involving all aspects of the clinical operations (Phase I). Phase II began in the fall of 2019 with all human clinical centers showing excellent progress towards initial recruitment goals and implementation of the protocol. The initial goal set forth by NIH was to recruit 270 children (10-17 years of age) and 1980 sedentary adults (age 18 years or greater) that are randomized to endurance training (170 youth, 840 adults), resistance training (840 adults), or non-exercise controls (50 youth, 300 adults). An additional group of highly active endurance (50 youth, 150 adults) and resistance (150 adults) trained individuals serve as comparators and are not participating in the MoTrPAC exercise training programs. The recruitment and enrollment approach are sex balanced and with participants across a wide range of ages (10-17, 18-39, 40-59 and >60-year age groups) and of different races. Due to the COVID-19 pandemic, MoTrPAC activities were suspended for over a year (beginning in March 2020) with continued constraints through 2022. Despite the numerous challenges encountered as a result of the pandemic, recruitment activities at the adult and pediatric clinical centers have accelerated to a rate that is projected to successfully achieve the target enrollment numbers by the end of the new award period. This led to the NIH Common Fund to release the current NOFO (RFA-RM- 23-010) to provide MoTrPAC with funding to complete recruitment and follow-up for the clinical studies, including finishing mechanistic randomized controlled trials of sedentary adults and children and observational studies of highly active adults and children. This will enrich the participant cohorts that are critical to understand exercise adaptations and heterogeneity across age, gender, and minority groups. Altogether, this extension will allow MoTrPAC to complete the intended goals as originally envisioned and will provide a more complete public database of the health benefits of exercise and provide insight into how physical activity mitigates disease.