SCIENCE FOR THE NEW MILLENNIUM--HS CANCER RES PARTNER

描述：(申请者描述)新世纪科学：高等 学校癌症研究伙伴关系。发展最快、变化最快 今天的研究领域是人类癌症遗传学。然而，很多东西 公众通过媒体了解癌症遗传学，而且它可以 误导性的或完全错误的。我们如何教育公众有关基因的知识 会导致癌症的变化？我们如何激发下一代的想象力 新一代癌症研究人员？一种方法是将最新的 癌症遗传学理论与当代高中生物学研究 课程设置。高中是许多人最后一次正式地 科学培训；它提供了接触更大细分市场的理想机会 人口中的一部分。实践证明，基于探究的学习是 最有效的方法将新的科学信息引入 课程设置。这项计划将使俄亥俄州立大学的科学家 综合性癌症中心与来自各地的高中生接触 俄亥俄州中部在他们的教室里进行癌症研究。这项建议是 基于一个非常成功的试点项目的结果。它结合了癌症 有短期研究经验的教育，每个学生约1,000人 年。 这一合作将把高科技研究设备带入课堂， 在那里，学生们可以学习癌症遗传学并获得第一手资料 癌症研究导论。使用PCP，试剂盒特别是 专为高中教室设计的，学生们将分离出自己的DNA 并将他们的基因“指纹”与肿瘤细胞系的DNA进行比较。 学生还将准备、分析和比较二倍体细胞的染色体。 与来自肿瘤细胞系的那些细胞系相一致。类还将使用新的 制定了NCI-NIH课程补充材料。 学校将通过竞争性申请被选中参与 流程，对于四个不同的地理部分具有相同的代表性 大哥伦布地区(大约200万人)，覆盖了一些 20个学区。为了确保这一点的实施和成功 合作，参与学校的教师将接受暑期培训 然后帮助将该项目融入他们的课堂。铅 在技术方面有经验的教师将设计培训 课程，并将与新的参与学校在整个 年。 我们将创建、实施、评估和传播一个全面的、 针对高中生和他们的老师的教育计划，重点是 关于癌症发展和易感性中发生的基因变化。 目前，还没有关于这一主题的高中课程材料。 也没有培训让教师做好准备，与他们的 学生们。这种创新的、亲力亲为的科学教育伙伴关系将会改变 学生对基因改变的知识、态度和做法 与癌症相关，并培养对癌症研究的兴趣 职业生涯。

DESCRIPTION: (Applicant's Description) Science for the New Millennium: High School Cancer Research Partnership. The most rapidly advancing and changing field in research today is human cancer genetics. However, much of what the public learns about cancer genetics is through the media and it can be misleading or simply wrong. How do we educate the public about the genetic changes that result in cancer? How do we spark the imagination of the next generation of cancer researchers? One way is to incorporate the latest in cancer genetics theory and research into current high school biology curriculum. High school is the last time many people will have any formal training in science; it affords an ideal opportunity to reach large segments of the population. Hands on, inquiry based learning has been shown to be the most effective method to introduce new scientific information into the curriculum. This program would put scientists from the Ohio State University Comprehensive Cancer Center in touch with high school students from around central Ohio to conduct cancer research in their classroom. This proposal is based on the results of a highly successful pilot project. It combines cancer education with a short-term research experience for about 1,000 students each year. This partnership will bring high-tech research equipment into the classroom, where students can learn about cancer genetics and have a first hand introduction to cancer research. Using PCP, kits which are specifically designed for the high school classroom, students will isolate their own DNA and compare their genetic "fingerprint" to that of DNA from tumor cell lines. Students will also prepare, analyze and compare chromosomes from diploid cell lines with those from tumor cell lines. Classes will also use the newly developed NCI-NIH curriculum supplement. Schools will be chosen to participate through a competitive application process, with equal representation for four different geographic sections of the greater Columbus area (approximately two million people) and covering some 20 school districts. To ensure the implementation and success of this partnership, teachers from participating schools will receive summer training and then assistance in integrating the program into their classrooms. Lead teachers who are experienced in the technologies will design the training sessions and will be paired with new participating schools throughout the year. We will create, implement, evaluate and disseminate a comprehensive, model education program for high school students and their teachers, which focuses on the genetic changes that occur in cancer development and predisposition. Currently, there is neither high school curriculum materials on this subject nor training to prepare teachers to share this information with their students. This innovative, hands on science education partnership will change student knowledge, attitudes and practices concerning the genetic alterations associated with cancer and cultivate an interest in cancer research as a career.