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Pushing the Boundaries of Multi-modal Biospectroscopic Microscopies

Pushing the Boundaries of Multi-modal Biospectroscopic Microscopies
突破多模态生物光谱显微镜的界限
批准号:
DP140100176
负责人:
Prof Peter Lay
金额:
$36.31万
依托单位:
依托单位国家:
澳大利亚
项目类别:
Discovery Projects
财政年份:
2014
资助国家:
澳大利亚
项目状态:
已结题
起止时间:
2014-01-01 至 2017-12-31

项目摘要

项目成果

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中文摘要
翻译
为了了解生命过程、疾病及其治疗的基本原理,必须探索细胞、组织和整个生物体中分子过程的基本变化。我们对这些过程的大部分理解都涉及到生物光谱学的化学探针的引入,但这些都有固有的问题,因为探针经常会改变被探测的生物化学。该项目将推动各种微米和纳米“无探针”显微镜的界限,为这些生命过程提供基本见解,最终可能导致疾病诊断,预防和治疗的改进。
英文摘要
In order to understand the fundamentals of life processes, diseases, and their treatments, it is essential to probe fundamental changes in molecular processes in cells, tissues and whole organisms. Much of our understanding of these processes has involved the introduction of chemical probes for biospectroscopy, but these have inherent problems because the probe can often change the biochemistry that is being probed. This project will push the boundaries of a variety of micro and nano "probe-free" microscopies to provide fundamental insights into these life processes, which could ultimately lead to improvements in the diagnosis, prevention and treatment of diseases.
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Metal Virulence and Therapeutic Factors in Pathogen Bioinorganic Chemistry
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