PhD Training Program in Virology and Gene Therapy

项目摘要 生命科学中统一的科学原理继续在病毒系统中被发现。基因治疗和 溶瘤病毒疗法依赖于病毒载体。意识到对基础病毒学的深刻理解是 基因治疗发展的需要导致了病毒学和基因治疗(VGT)的建立 2004年梅奥临床生物医学研究生院(MCGSBS)跟踪；自2018年以来，NIH支持 它最好的三名博士前学生。博士培训利用基础研究的力量和强大的 梅奥诊所的翻译基础设施。培训在22名VGT教职员工的实验室进行。 8人来自分子医学系，3人来自内科肿瘤学，2人来自感染性疾病 疾病、血液学和生物化学/分子生物学。其他人来自五个不同的部门。这个 在病毒、媒介、人类疾病机制、癌症治疗、 和基因疗法。VGT的流行在一定程度上是基于它在病毒学和 翻译病毒和基因疗法。在论文的整个时间里，学生们全神贯注地进行着 计划活动，包括期刊俱乐部、系列研讨会、年度静修和国家科学 开会。VGT轨道的要求符合MCGSBS的一般要求。美国国立卫生研究院继续 三名受训人员的支持将使这一成功和创新的方案得到进一步发展。

Project Summary Unifying scientific principles in the life sciences continue to be discovered in viral systems. Gene therapy and oncolytic virotherapy depend on viral vectors. Awareness that a deep understanding of fundamental virology is necessary for the development of gene therapy led to the foundation of the Virology and Gene Therapy (VGT) track of Mayo Clinic Graduate School of Biomedical Sciences (MCGSBS) in 2004; since 2018 the NIH supports three of its best pre-doctoral students. Ph.D. training leverages the strength of basic research and the robust translational infrastructure at Mayo Clinic. Training is performed in the laboratories of 22 VGT faculty members. Eight are from the Department of Molecular Medicine, three from Medical Oncology, two each from Infectious Diseases, Hematology, and Biochemistry/Molecular Biology. The others are from five different departments. The faculty is united by leadership in research on viruses, vectors, mechanisms of human disease, cancer treatment, and gene therapy. VGT popularity is based in part on its unique training opportunities in both virology and the translation of viral and gene therapeutics. During the entire time of their thesis the students engage in a full array of programmatic activities including journal clubs, seminar series, an annual retreat and national scientific meetings. Requirements for the VGT track conform to the general requirements of MCGSBS. Continued NIH support of three trainees would allow further development of this successful and innovative program.