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Optimizing Measurement Of Hiv-1 Neutralization Using A

Optimizing Measurement Of Hiv-1 Neutralization Using A
使用 A 优化 HIV-1 中和测量
批准号：
6822171
负责人：
John R Mascola
金额：
$0.0万
依托单位：
NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES
依托单位国家：
美国
项目类别：
财政年份：
--
资助国家：
美国
项目状态：
未结题
起止时间：
至
来源：
https://reporter.nih.gov/project-details/6822171
关键词：
AIDS vaccines flow cytometry human immunodeficiency virus 1 human tissue method development monoclonal antibody neutralizing antibody polymerase chain reaction tissue /cell culture

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中文摘要
翻译
目前正在深入研究新型人类免疫缺陷病毒1型（HIV-1）疫苗免疫原的设计，可以引发有效的中和抗体。比较和优化这些策略的先决条件是精确测量中和抗体应答的能力。为此，我们试图开发一种直接定量外周血单核细胞（PBMC）单轮HIV-1感染的检测方法。该测定的精密度和重现性将有助于测量HIV-1中和，特别是新候选疫苗产生的逐步改善的中和抗体应答。
英文摘要
There is currently intensive research on the design of novel human immunodeficiency virus type 1 (HIV-1) vaccine immunogens that can elicit potent neutralizing antibodies. A prerequisite for comparing and optimizing these strategies is the ability to precisely measure neutralizing antibody responses. To this end, we sought to develop an assay that directly quantifies single-round HIV-1 infection of peripheral blood mononuclear cells (PBMC). The precision and reproducibility of this assay will facilitate the measurement of HIV-1 neutralization, particularly incrementally improved neutralizing antibody responses generated by new candidate vaccines.
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会议论文
PASSIVE ANTIBODY PROTECTION IN SHIV CHALLENGE MODEL
PASSIVE ANTIBODY PROTECTION IN SHIV CHALLENGE MODEL
PASSIVE ANTIBODY PROTECTION IN SHIV CHALLENGE MODEL
Immunogenicity Studies of HIV-1 immunogens
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