GENETIC CORRELATES WITH PROPENSITY FOR HANGOVER: AN EXPLORATORY STUDY

这个子项目是许多利用 由NIH/NCRR资助的中心赠款提供的资源。子项目和 研究者（PI）可能从另一个NIH来源获得了主要资金， 因此可以在其他CRISP条目中表示。所列机构为 研究中心，而研究中心不一定是研究者所在的机构。 本遗传学子研究拟从方案H-22722（宿醉、同源物、睡眠和职业表现）和H- 23064（醉酒对学生表现的残留影响）中自愿参与本研究的研究参与者池中采集脸颊上皮（皮肤）细胞样本，用于DNA分析。这项分析的目的是评估是否宿醉的倾向，可能是由酒精脱氢酶基因（ADH）的遗传差异调节。遗传学数据与母项目（H-22722）和（H-23064）的数据相结合，将使这项探索性研究成为可能。 在知情同意程序之后，将要求参与者通过用棉签摩擦脸颊内侧来收集皮肤细胞样本。该程序不会引起任何风险或不适。遗传样本将被送至普罗维登斯退伍军人管理局医疗中心的研究合作研究者进行分析。所有样本将在数据分析后销毁，除非受试者同意将样本储存长达10年，以便能够检测与宿醉病因学相关的候选基因。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. This genetics sub study proposes to collect a sample of cheek epithelial (skin) cells for the purpose of DNA analysis from the pool of study participants in protocols H-22722 (Hangover, Congener, Sleep and Occupational Performance) and H- 23064 (Residual Effects of Intoxication on Student Performance) who volunteer for this study. The objective of this analysis is to assess whether the propensity for hangover, may be moderated by genetic differences in the alcohol dehydrogenase gene (ADH). Genetics data combined with data from the parent projects (H-22722) and (H-23064) will enable this exploratory research. Following consent procedures, participants will be asked to collect samples of skin cells by rubbing the inside of their cheeks with a cotton swab. This procedure is not known to cause any risks or discomforts. Genetic samples will be sent to the study Co-Investigator at Providence Veterans Administration Medical Center for analysis. All samples will be destroyed following data analysis, unless the participant consents to having the sample stored for up to 10 years to enable testing of candidate genes related to hangover etiology.