REPETITIVE TMS TO IMPROVE SPEECH IN APHASIA

这个子项目是许多研究子项目中利用 资源由NIH/NCRR资助的中心拨款提供。子项目和 调查员(PI)可能从NIH的另一个来源获得了主要资金， 并因此可以在其他清晰的条目中表示。列出的机构是 该中心不一定是调查人员的机构。 据估计，目前美国失语症患者有100万人，每年新增8万人。需要新的治疗方法，特别是在美国人口年龄增加的情况下。本研究旨在探讨重复性经颅磁刺激(RTMS)能否改善慢性卒中非流利性失语患者的言语功能。之前使用功能磁共振成像的研究发现，说话不流利的人右侧大脑半球某些区域的血流量过多(推测皮质兴奋性异常增加)。假设，在两周的时间里，对失语症患者的右侧运动皮质或其他右半球感兴趣区域进行10次1赫兹的真实rTMS治疗，将显著提高说出图片的能力，并显著改善命题语音。假冒的rtms对相同的感兴趣区域没有任何影响。除了招募失语症受试者外，一组正常对照组也将参加这项研究。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The number of people with aphasia in the US today is estimated to be 1 million with 80,000 new cases each year. New therapeutic treatments are needed, especially in light of increases in the age of the US population. The purpose of this study is to investigator whether repetitive transcranial magnetic stimulation (rTMS) can be used to improve speech in chronic stroke patients with nonfluent aphasia. Previous work using fMRI has identified excess blood flow (presumed abnormal increase in cortical excitability) in certain areas of the right hemisphere in individuals with nonfluent speech. It is hypothesized that ten sessions of real rTMS at 1 Hz given over a two week period to the right motor cortex or other right hemisphere regions of interest specific for that aphasia patient, will significantly improve ability to name pictures and significantly improve propositional speech. Sham rTMS to the same regions of interest is hypothesized to have no effect. In addition to enrolling subjects with aphasia, a group of normal controls will also be enrolled in this study.