EFFECT OF HYPOXIA ON INTERSTITIAL METABOLITES & SKELETAL MUSCLE BLD FLOW IN OSA

这个子项目是许多研究子项目中的一个 由NIH/NCRR资助的中心赠款提供的资源。子项目和 研究者（PI）可能从另一个NIH来源获得了主要资金， 因此可以在其他CRISP条目中表示。所列机构为 研究中心，而研究中心不一定是研究者所在的机构。 在这项研究中，研究人员将测试这一假设，即神经血管对缺氧的反应是改变阻塞性睡眠呼吸暂停（OSA）。 研究人员将测量10分钟急性缺氧对OSA患者和对照组的肌肉交感神经活动（神经血管收缩信号）、血管舒张剂和血管收缩剂因子在动脉和肢体血流中释放的影响。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. In this study the investigators will test the hypothesis that the neurovascular response to hypoxia is altered in obstructive sleep apnea (OSA). The investigators will measure the effects of 10 minutes of acute hypoxia on muscle sympathetic nerve activity (neural vasoconstrictor signal), vasodilator and vasoconstrictor factors released in the interstitium and limb blood flow in patients with OSA and in controls.