Claude D Pepper Older Americans Independence Center

描述(申请人提供)：马里兰大学OAIC更新的使命是进行基于运动和运动学习的康复研究，以优化遭受中风、髋部骨折或其他慢性衰弱疾病的老年人的康复，并将这些发现转化为有效的基于社区的康复计划。这将通过具体目标来实现：1)开展基础和临床研究，研究与慢性老年病相关的功能障碍的潜在机制，以确定定义神经运动、肌肉、代谢、心血管和心理社会功能领域的残疾表型的功能障碍的特征；2)应用这些科学发现，设计新的基于运动和运动学习的康复策略；3)确定这些康复干预改善患有功能障碍的老年人的功能和临床结果的机制；4)将有效的康复策略转化为以社区为基础的临床研究；5)支持探索核心(P/EC)试点项目，这些项目研究残疾表型的潜在机制以及康复的功能和临床反应；以及6)将初级教师奖获得者(JFA)的职业发展培养成老龄化研究的独立研究人员和学术领袖。我们研究残疾和老龄化康复的动力是它对患有慢性残疾的老年人的健康和生活质量至关重要，以及在这一调查领域缺乏机械性和翻译性研究。马里兰大学OAIC拥有一支经验丰富的领导团队，在老龄化研究、管理和监测大型项目方面具有专长，并组建和激励一支多学科的调查团队。有一个研究职业发展核心(RCDC)，提供以导师为基础的培训计划，以促进JFA的职业发展，P/EC包括5个与OAIC目标一致的研究，以及1)临床和翻译研究方法，2)神经运动功能，3)应用临床生理学，4)肌肉生物学和炎症分子机制，以及5)生物统计学和信息学。我们乐观地认为，马里兰大学OAIC的研究将通过开发创新的、基于证据的运动和运动学习康复计划来改变临床实践，改善老年残疾人的功能和临床结果，促进他们的康复和独立生活。

DESCRIPTION (provided by applicant): The mission of the University of Maryland OAIC renewal is to conduct exercise and motor learning based rehabilitation research to optimize the recovery of older adults who have suffered a stroke, hip fracture or other chronic debilitating disease, and translate these findings into effective community-based rehabilitation programs. This will be accomplished through specific aims to: 1) conduct basic and clinical research examining the mechanisms underlying functional disabilities associated with chronic diseases of aging to characterize the functional impairments that define the disability phenotype across domains of neuromotor, muscular, metabolic, cardiovascular and psychosocial function; 2) apply these scientific findings to design novel exercise and motor learning-based rehabilitation strategies; 3) determine the mechanisms by which these rehabilitation interventions improve functional and clinical outcomes in older people with functional impairments; 4) translate efficacious rehabilitation strategies into community-based clinical studies; 5) support Pilot Exploratory Core (P/EC) Projects that study the mechanisms underlying the disability phenotype and functional and clinical responses to rehabilitation; and 6) foster the career development of junior faculty awardees (JFA's) into independent investigators and academic leaders in aging research. Our impetus to study rehabilitation in disability and aging is its critical importance for the health and quality of lifestyle older people living with chronic disability, and the dearth of mechanistic and translational research in this area of investigation. The UNIVERSITY OF MARYLAND-OAIC has an accomplished leadership team with expertise in aging research, administration and monitoring large programs, and assembling and motivating a multidisciplinary team of investigators. There is a Research Career Development Core (RCDC) that provides a mentor-based training program to promote the career development of JFA's, a P/EC with 5 studies congruent with OAIC goals, and 5 RCs in 1) Clinical and Translational Research Methods, 2) Neuromotor Function, 3) Applied Clinical Physiology, 4) Muscle Biology and Molecular Mechanisms of Inflammation, and 5) Biostatistics and Informatics. We are optimistic that UNIVERSITY OF MARYLAND-OAIC's research will change clinical practice by developing innovative, evidence-based exercise and motor learning rehabilitation programs that improve the functional and clinical outcomes of older people with disabilities to promote their recovery and independent living.