DEVELOPMENT PSYCHOPATHOLOGY MODULE

发展精神病理学模块的首要目标是阐明与物质使用障碍(SUD)、易感性和结果有关的精神病理学的个体发生。在拟议的资助期内，将测试的假设集中在青春期晚期和成年期早期(19-22岁)之间的精神病理学和SUD结果。此外，还将研究精神病理学与先兆和同时代心理特征之间的联系，特别是认知、情感和行为。 监管失调。这些后一种特征被认为是自发性精神障碍的组成部分(见科学核心第2.4.6节)，并已被证明是早于精神病理学的。与雪松的表观遗传学框架一致，心理调节失调被假设为易患精神病理学，而精神病易患酒精、烟草和其他药物(ATOD)的使用，从而导致SUD。对患有严重精神障碍的高危儿童以及符合严重精神障碍的青少年的研究，包括Cedar的发现，已经报告了精神病理学的两个领域的优势：(1)破坏性行为障碍(明显反映行为失调)；(2)消极情绪障碍(显著反映情绪失调)。 发展精神病理学模块建议前瞻性地检查从童年到成年早期的精神病理学特征。使用Cedar的前瞻性范式，这个模块将确定精神病理学预测ATOD参与的启动和加速最终导致SUD的程度。与该中心的其他单元一起，将在成熟和环境特征的背景下审查精神病理学对SUD风险和结果的影响和相互作用。在这种背景下，精神病理学既是心理调节失调的结果(见图1) 以及后续结果的先兆，特别是SUD。

The overarching goal of the Developmental Psychopathology Module is to elucidate the ontogeny of psychopathology in relation to substance use disorder (SUD) liability and outcome. During the proposed funding period, the hypotheses to be tested focus on psychopathology and SUD outcomes between late adolescence and early adulthood (ages 19-22). In addition, research will be condcuted to examine the association between psychopathology and precursor as well as contemporaneous psychological traits, particularly cognitive, affective and behavioral dysregulation. These latter traits are hypothesized to be integral to SUD liability (see Scientific Core section 2.4.6) and have been shown to antedate psychopathology. Consistent with CEDAR's epigenetic framework, psychological dysregulation is hypothesized to predispose to psychopathology which in turn predispose to alcohol, tobacco and other drug (ATOD) use and consequently lead to SUD. Studies of children at high risk for SUD, as well as adolescents qualifying for SUD, including CEDAR findings, have reported the predominance of two domains of psychopathology: (1) disruptive behavior disorders (saliently reflecting behavioral dysregulation); and, (2) negative affect disorders (saliently reflecting emotional dysregulation). The Developmental Psychopathology Module proposes to prospectively examine psychopathological characteristics from childhood through early adulthood. Using CEDAR's prospective paradigm, this module will determine the extent to which psychopathology predicts initiation and acceleration of ATOD involvement culminating in SUD. In conjunction with the Center's other modules, the influence and interaction of psychopathology on SUD liability and outcome will be examined in the context of maturational and environmental characteristics. In this context, psychopathology is both an outcome of psychological dysregulation (see Figure 1) and a precursor of subsequent outcomes, specifically SUD.