THE MANHATTAN HIV BRAIN BANK

这个子项目是许多研究子项目中利用 资源由NIH/NCRR资助的中心拨款提供。子项目和 调查员(PI)可能从NIH的另一个来源获得了主要资金， 并因此可以在其他清晰的条目中表示。列出的机构是 该中心不一定是调查人员的机构。 曼哈顿艾滋病毒脑库(MHBB)是一个为神经艾滋病研究提供具有良好特征的人体组织和液体的资源。作为国家神经艾滋病组织联盟(NNTC)的一部分，它向广泛的调查人员分发材料，并开始了一项观察性调查计划。 在接下来的5年里，我们将继续并增加艾滋病毒感染患者向研究艾滋病毒发病机制的合格研究人员提供的信息、组织和液体，并继续招募艾滋病毒感染患者参加器官捐赠计划，在此之前，我们将进行神经学、神经心理学和精神病学的纵向研究。无论是单独还是与其他NNTC站点，我们都将检验传统的临床病理的死前功能与死后病理的相关性，并检验神经艾滋病疾病的纵向进展。 我们还将在HIV阴性对照队列中创建一个器官捐赠计划，作为病毒学控制材料的来源，并帮助剖析肝脏对神经艾滋病疾病的影响。具体地说，一组死亡风险明确的移植前肝病患者将被招募到器官捐赠计划和NNTC组合测试的纵向研究中。将继续关注艾滋病毒相关的CNS和PNS疾病的共病和健康差异，特别是在确定肝病、物质障碍和艾滋病毒对认知和神经功能障碍的贡献方面。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The Manhattan HIV Brain Bank (MHBB) is a resource that provides well-characterized human tissues and fluids for NeuroAIDS research. As part of the National NeuroAIDS Tissue Consortium (NNTC), it distributes materials to a wide range of investigators, and has begun a program of observational investigation. In the next 5 year period, we will continue and increase the provision of information, tissues, and fluids from HIV-infected patients to qualified researchers investigating HIV pathogenesis, and continue to recruit HIV-infected patients into an organ donation program preceded by a longitudinal neurologic, neuropsychologic, and psychiatric study. Both individually and with other NNTC sites, we will examine traditional clinico-pathologic correlations of premortem function with postmortem pathology, and to examine the longitudinal progression of neuroAIDS disorders. We will additionally create an organ donation program in an HIV-negative control cohort, that will serve as a source of virologic control materials and also aid in the dissection of hepatic influences on NeuroAIDS disorders. Specifically, a group of pre-transplant liver disease patients with well-defined risk of mortality will be recruited to an organ donation program and longitudinal study with the NNTC battery of tests. There will be a continued focus on co-morbidities and health disparities in HIV-related CNS and PNS disorders, particularly in defining contributions of liver disease, substance disorders, and HIV on cognitive and neurologic dysfunction.