ACTIVITY 4: BIOSTATISTICS AND COMPUTER CORE SUPPORT SERVICES

这个子项目是许多研究子项目中利用 资源由NIH/NCRR资助的中心拨款提供。子项目和 调查员(PI)可能从NIH的另一个来源获得了主要资金， 并因此可以在其他清晰的条目中表示。列出的机构是 该中心不一定是调查人员的机构。 这项活动的总体目标是扩大和加强生物统计数据管理设施和计算机网络支助设施的能力。主要业务重点是在生物统计分析、计算机建模、基于网络的数据输入、数据库开发和管理、数据存储、联网、连接、视频会议和培训方面提供最先进的服务，以满足夏威夷大学马诺阿分校快速增长的生物医学研究人员队伍的需要。CNSF最初是从1992年开始用RCMI基金开发的。BDMF成立于2004年，由RCMI基金资助。在2006-2011年供资周期中，生物统计框架的重点是增长和发展一个提供全面服务的生物统计核心，并为该设施今后的制度化制定计划。其具体目标是发展和提高生物统计学专门知识以及数据管理和计算机建模能力，以便为进行严格的生物医学研究提供必要的量化资源。开发的领域包括：1)计算多元统计程序的能量/样本量；2)将数据输入适用于存档和统计提取的分级数据管理系统的网络系统；3)重点放在多维神经元成像数据领域的结构方程建模；以及4)用于分析基因-环境相互作用的软件工具。CNSF的具体目标是满足生物医学研究人员在基于服务器的工具、高速计算、网络和无线连接、台式机和笔记本电脑支持、视频会议和数据呈现等领域不断发展的需求。发展领域包括：1)数据管理和数据库服务；2)网络和通信服务；3)桌面和演示服务。这些目标不仅指导每个设施的主要工作，而且为它们的合作和交叉提供蓝图。目前服务的客户包括90多名生物医学研究人员和许多其他教职员工和学生。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The overall goal of this activity is to expand and enhance the capabilities of both the Biostatistics Data Management Facility (BDMF) and the Computer Network Support Facility (CNSF). The primary operational focus is to deliver state-of-the-art services in biostatistical analysis, computer modeling, web-based data entry, database development and management, data storage, networking, connectivity, video conferencing and training to meet the needs of the fast-growing cadre of biomedical researchers at the University of Hawaii at Manoa. The CNSF was originally developed with RCMI funds beginning in 1992. The BDMF was established in 2004 with RCMI funds. In the 2006-2011 funding cycle the BDMF is focused on the growth and development of a full-service biostatistics core with plans for future institutionalization of the facility. The specific aim is to develop and increase biostatistical expertise and data management and computer modeling capacity in order to provide the quantitative resources essential for the conduct of methodologically rigorous biomedical research. Among the areas of development are: 1) calculation of power/sample size for multivariate statistical procedures; 2) a web-based system for data entry into a hierarchical data-management system suitable for archival and statistical extraction; 3) structural-equation modeling with emphasis in the area of multidimensional neuron-imaging data; and 4) software tools for the analysis of gene-environment interactions. The specific aim for the CNSF is to provide for the evolving needs of biomedical researchers in the areas of server-based tools, high-speed computation, network and wireless connectivity, desktop and laptop support, video conferencing and data presentation. Among the areas of development are: 1) data management and database services; 2) network and communication services; and 3) desktop and presentation services. These aims not only guide the major work of each facility but they provide the blueprint for their collaboration and intersection. Clients currently served include over 90 biomedical investigators and numerous other faculty, staff and students.