ACTIVITY 2: BIOACTIVE NUTRIENTS CORE

这个子项目是许多研究子项目中的一个 由NIH/NCRR资助的中心赠款提供的资源。子项目和 研究者（PI）可能从另一个NIH来源获得了主要资金， 因此可以在其他CRISP条目中表示。所列机构为 研究中心，而研究中心不一定是研究者所在的机构。 生物活性营养素活动的总体目标是研究可能对人类疾病预防有效的营养成分，并且是诊断后治疗中使用的更常规程序或治疗方法的高度成本效益，非侵入性替代品。 鉴于重大的健康问题，是服从于饮食干预，并在夏威夷这一行动过程中的潜力，我们的长期目标是使用多学科，翻译的方法来理解的分子，细胞和生物机制背后的营养为基础的疾病预防在人类中，在其他模型系统的初步研究。生物活性营养素活动促进了有前途的年轻研究人员的研究项目，其中一个项目涉及膳食补充剂硒对小鼠模型急性和慢性哮喘发展的影响，另一个项目研究亚洲蔬菜苦瓜成分在体内和体外减少肥胖和胰岛素抵抗的功效。 显微镜和其他成像方法是广泛的生物医学研究工作中的关键技术。 UHM的NCRR和其他外部支持计划的数量迅速扩大，导致在协调和优先考虑相互竞争的研究基础设施需求和科学目标方面面临更大的挑战。 显微镜和成像核心设施的总体目标是将各种显微镜和其他成像系统整合到一个核心设施中，以最大限度地利用这些资源，汇集各种专业知识和技术，并促进方法和试剂的合作和交流。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The overall goal of the Bioactive Nutrients activity is to investigate nutritional components that may have efficacy in human disease prevention and are highly cost-effective, non-invasive alternatives to the more conventional procedures or therapeutics utilized in post-diagnosis treatment. Given the significant health problems that are amenable to dietary intervention, and the potential for this course of action in Hawaii, our long-term goals are to use multidisciplinary, translational approaches to understand the molecular, cellular and organismal mechanisms behind nutrition-based disease prevention in humans, based on preliminary studies in other model systems. The Bioactive Nutrients activity fosters research projects by promising young investigators, one dealing with the effects of the dietary supplement selenium on the development of acute and chronic asthma in a mouse model, the other investigating the efficacy of components in an Asian vegetable, bitter melon, to reduce adiposity and insulin resistance in vivo and in vitro. Microscopy and other imaging methods are critical techniques in a broad range of biomedical research endeavors. Rapid expansion in the number of NCRR- and other extramurally-supported programs at UHM, has resulted in far greater challenges in the coordination and prioritization of competing research-infrastructure needs and scientific goals. The overall goal of the Microscopy and Imaging Core Facility is to consolidate a variety of microscopes and other imaging systems into a single core facility to maximize use of these resources, bring together diverse expertise and technology, and foster collaboration and exchange of methodologies and reagents.