Potential Beneficial Role of Hip Muscles in Knee OA Progression

存在预防膝骨性关节炎疾病进展或骨性关节炎相关残疾的策略，这在很大程度上是由于有限的 对造成这些结果的因素的了解。近几年来，在 流行病学研究更侧重于膝骨性关节炎的进展而不是最初的发展。 此外，人们越来越认识到局部因素在进展中的作用，特别是那些修改 联合装载。最近的发现支持臀部肌肉力量可能在膝关节中发挥重要作用。 膝骨性关节炎患者的防护。 在这项应用中，我们建议检查髋部肌肉力量的影响，特别是髋外展肌群。 和外旋肌力量，对膝骨性关节炎疾病进展、身体功能下降和残疾 膝骨性关节炎患者的进展情况。拟议的目标是以我们正在进行的研究的结果为基础的。一个 拟议项目的长期目标是为利用髋关节的干预发展提供信息。 肌肉有益于膝盖骨关节炎患者。我们建议对一个队列进行2次评估(基线评估和2年评估) 在膝盖骨关节炎中，我们将测量臀部肌肉的力量，并收集X光照片、磁学数据 磁共振成像(MRI)、功能状态和残疾数据，以分析髋关节的关系 两组之间的OA疾病、身体功能和残疾程度恶化的基线参数 基线和后续行动，使用最先进的方法评估每个结果。该设备，脉搏 序列和MR方案的质量支持对关节软骨的定量评估。 这项研究的结果将为膝骨性关节炎的物理和康复治疗的发展提供参考 这可能会利用臀部肌肉系统的优势。这是膝关节的一个关键的、可修改的方面 在膝盖骨关节炎中很少受到关注的环境，尽管髋部肌肉在膝盖骨关节炎中可能发挥着重要作用 既有膝部水平的功能，也有人体水平的功能。拟议的研究将包括磁共振成像的结构结果和 通过X光检查，通过自我报告和任务表现得出与人相关的结果。鉴于美国政府所扮演的角色 髋关节，臀部肌肉状态不仅与膝盖骨关节炎的进展有关，而且还与 功能受限和残疾。

strategies to prevent knee OA disease progression or OA-related disability exist, in large part due to limited knowledge of factors responsible for these outcomes. In recent years, there has been a shift in epidemiological studies towards heavier focus on progression than on the initial development of knee OA. Also, recognition of the role in progression of local factors is growing, especially those factors that modify joint loading. Recent findings support that hip muscle forces may play an important role in knee joint protection in persons with osteoarthritic knees. In this application, we propose to examine the effect of hip muscle strength, particularly hip abductor and external rotator strength, on knee OA disease progression, physical function decline, and disability progression in persons with knee OA. The proposed aims build upon results from our ongoing study. A long-term goal of the proposed project is to inform intervention development that capitalizes upon the hip muscles to benefit persons with knee OA. We propose 2 evaluations (at baseline and at 2 years) of a cohort with knee OA, in which we will measure strength of hip muscles as well as collect radiographic, magnetic resonance imaging (MRI), functional status, and disability data, in order to analyze the relationship of the hip parameters at baseline to worsening of OA disease, physical function, and disability measures between baseline and follow-up, using state-of-the-art approaches to assess each outcome. The equipment, pulse sequences, and quality of the MR protocol support quantitative assessment of articular cartilage. The results of this study will inform development of physical and rehabilitative therapy for knee OA that might take advantage of the hip musculature. This is a key, modifiable aspect of the knee joint environment that has received little attention in knee OA, despite a potentially large role of hip muscles in both knee-level and person-level function. The proposed study will include structural outcomes by MRI and by x-ray and person-relevant outcomes by self-report and task performance. Given the role played by the hip, it is plausible that hip muscle status will be linked not only to knee OA progression but also to associated function limitation and disability.