STRATEGIES FOR THE TREATMENT OF HIV ASSOCIATED METABOLIC SYNDROME

这个子项目是许多研究子项目中的一个 由NIH/NCRR资助的中心赠款提供的资源。子项目和 研究者（PI）可能从另一个NIH来源获得了主要资金， 因此可以在其他CRISP条目中表示。所列机构为 研究中心，而研究中心不一定是研究者所在的机构。 HIV相关的代谢综合征，其特征是身体脂肪再分布、血脂异常和胰岛素抵抗，在接受高效抗逆转录病毒治疗（HAART）的患者中经常观察到。 其潜在机制尚不清楚。 然而，代谢异常的存在，包括血脂异常和内脏肥胖，提示HIV感染患者发生心血管疾病的风险增加，特别是考虑到与HAART相关的生存期延长。 目前，对于这种综合征还没有确定的治疗方案。 然而，由于饮食和运动改善了HIV阴性个体的代谢状况，因此探索这些策略对HIV阳性患者的潜在有益影响非常重要。 在这项研究中，我们将集中在确定最佳方案的艾滋病毒感染的代谢综合征患者的生活方式改变，结合胰岛素增敏剂（二甲双胍）和渐进式阻力训练进行评估。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. HIV-associated metabolic syndrome, characterized by body fat redistribution, dyslipidemia, and insulin resistance, is frequently observed in patients treated with highly active antiretroviral therapy (HAART). The underlying mechanisms are still unknown. However, the presence of metabolic abnormalities, including dyslipidemia and visceral adiposity, suggests an increased risk for developing cardiovascular disease in HIV-infected patients, especially given the prolonged duration of survival associated with HAART. Presently, there are no established treatment options for this syndrome. However, because diet and exercise has improved the metabolic profile of HIV negative individuals, it is important to explore the potential beneficial effects of such strategies in HIV-positive patients. In this study we will focus on determining the optimal program for HIV-infected patients with the metabolic syndrome by evaluating lifestyle modification in combination with insulin sensitizing agents (metformin) and progressive resistance training.