LOOK AHEAD: ACTION FOR HEALTH IN DIABETES

这个子项目是许多研究子项目中利用 资源由NIH/NCRR资助的中心拨款提供。子项目和 调查员(PI)可能从NIH的另一个来源获得了主要资金， 并因此可以在其他清晰的条目中表示。列出的机构是 该中心不一定是调查人员的机构。 前瞻的主要目标是在患有2型糖尿病的超重志愿者中检查强化生活方式干预计划的长期效果，该计划旨在通过减少卡路里摄入量和增加体力活动来实现和保持减肥。这项计划与接受糖尿病支持和教育的对照组进行了比较。将在两个治疗组之间进行比较的主要结果是严重心血管事件的发生率。其他结果包括心血管疾病风险因素、糖尿病相关代谢因素和并发症，以及强化干预的成本效益。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The primary objective of Look AHEAD is to examine, in overweight volunteers with type 2 diabetes, the long-term effects of an intensive lifestyle intervention program designed to achieve and maintain weight loss by decreased caloric intake and increased physical activity. This program is compared to a control group receiving diabetes support and education. The primary outcome, which will be compared between the two treatment groups, is the incidence of serious cardiovascular events. Other outcomes include cardiovascular disease risk factors, diabetes-related metabolic factors and complications, and cost-effectiveness of the intensive intervention.