SEARCH FOR DIABETES IN YOUTH OF THE PUGET SOUND

这个子项目是众多研究子项目之一

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. SEARCH for Diabetes in Youth is a national, multi-center, uniform approach to case ascertainment, typology, surveillance, and research on diabetes in children and adolescents that will measure the extent of diabetes in the US population of youth under the age of twenty by type of diabetes, age, gender and race / ethnicity. Secondary objectives include developing practical approaches to identifying diabetes type, describing childhood diabetes and its complications by type, and characterizing health care utilization, processes of care and quality of life. SEARCH is collecting information through limited data, surveys, brief physical examinations (height, weight, blood pressure, waist to hip measurement and assessment for acanthosis nigricans), laboratory studies (diabetes autoantibodies, fasting and stimulated C-peptide, hemoglobin A1c, blood glucose, lipids, urine albumin, creatinine, DNA extraction, and plasma storage), and interview surveys (date and setting of diagnosis; clinical presentation, age and body size at diagnosis; other medical history and use of prescription medications; race / ethnicity and socioeconomic status, family structure, and quality of life). Additional questions about health behaviors (diet, activity, sleep and smoking and depression) are being asked of youth over age 10. Incident cases will be followed yearly in order to define the evolution of diabetes and assess the occurrence of complications. SEARCH will estimate the prevalence and incidence of diabetes in youth less than 20 years or by type, develop typology schemes to characterize diabetes in youth, document risk factors and processes of care, and establish an infrastructure for long-term follow-up.