HORMONAL REGULATORS OF MUSCLE AND METABOLISM IN AGING (HORMA)--1 R01 AG18169-01

这个子项目是许多研究子项目中利用 资源由NIH/NCRR资助的中心拨款提供。子项目和 调查员(PI)可能从NIH的另一个来源获得了主要资金， 并因此可以在其他清晰的条目中表示。列出的机构是 该中心不一定是调查人员的机构。 老年人的骨骼肌群、肌力、日常生活活动的功能能力逐渐丧失，情绪受损，最终失去独立性。衰老也与性腺功能和生长激素(GH/IGF-Laxis)的完整性丧失有关。然而，这些激素轴的缺乏与骨骼肌减少和衰老时的脆弱之间的关系，或者这两种激素系统在维持正常肌肉质量和功能方面是否存在相互作用，还没有建立起来。我们假设这两种激素系统通过不同和互补的机制调节肌肉骨骼蛋白质量和收缩纤维，睾酮和GH/IGF-1的最佳水平对于维持骨骼肌质量、肌肉力量、日常生活的全面功能活动、生活质量和衰老过程中的独立性是必要的。这项研究的结果应该导致重要的机制理解雄激素缺乏和发育不良在与肌肉质量和力量减少相关的虚弱的老年人中的相对作用。这一结果也应该为未来测试新的、新的治疗策略提供有价值的信息，这些策略在老年相关的骨质疏松症和虚弱的患者中比肠外治疗更耐受和方便。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Elderly persons experience progressive loss of skeletal muscle mass, muscle strength, functional capacity for activities of daily living, have impaired mood, and eventually lose independence. Aging is also associated with a loss of gonadal function and integrity of the growth hormone (GH/IGF-laxis. However, the relationship of deficiencies of these hormones axes to sarcopenia and frailty in aging has not been established or whether there is an interactions of these two hormone systems in maintaining normal muscle mass and function. We hypothesize that both hormone systems regulate musculoskeletal protein mass and contractile fibers by different and complimentary mechanisms and that optimal levels of both testosterone and GH/IGF-1 are necessary to maintain skeletal muscle mass, muscular strength, full functional activities of daily living, quality of life, and independence during the aging process. The findings of this study should result in important mechanistic understanding of the relative contributions of androgen deficiency and hyposomatotropism in elderly persons with frailty related to decreased muscle mass and strength. The results should also provide valuable information for future testing of new, novel treatment strategies which are more tolerable and convenient than parenteral therapies in age associated sarcopenia with frailty.