2011 CSHL Yeast Cell Biology Conference

描述(由申请人提供)：过去十年的研究促进了我们对构成细胞功能的分子机制的理解的巨大进步。进展来自多种细胞类型和生物体。值得注意的是，酵母系统在发现新的蛋白质、途径、结构和机械洞察方面往往走在了前列。尽管酵母作为单细胞生物体存在，但对多细胞生物体的生理学和特殊组织的功能的研究也揭示了意想不到的见解。酵母细胞生物学仍然是一个充满活力的研究领域，酵母系统作为新概念和新技术的试验台，对更大的研究社区至关重要。酵母细胞生物学系列会议(2011、2013和2015)的学术价值在于，它将为讨论和交流关于真核细胞内部功能的前沿发现创造一个主要论坛。该计划将包括八个课程，涵盖细胞生物学的广泛主题，包括膜运输、细胞骨架、细胞周期、极性、染色体、核组织和信号传递，重点是整合这些不同事件的更高级别的调控。每一次会议将由相关领域的两名杰出和知名的调查人员领导。除了会议主席发表的简短演讲外，所有的演讲和海报都将从提交的摘要中挑选出来，大部分演讲将由学生、博士后研究员和其他初级研究人员进行。预计将有超过275名科学家参加。其中，超过一半的人可能是研究生和博士后研究员。这次会议将为在细胞生物学知识前沿对一些最令人兴奋的数据和概念进行自由流动的讨论提供一个刺激的环境。鉴于该领域的快速发展，这次会议为与会者提供了一个令人兴奋的机会，让他们了解最近的突破，这些突破将与他们自己在酵母和其他系统中的研究相关。拟议活动的更广泛影响是多方面的。首先，它们包括对酵母细胞生物学以外的其他领域的科学影响，因为该领域的发现将继续促进影响所有生命形式的生理学的基本发现和见解的快速发展。其次，它们还包括教育、培训、资源共享以及互动和合作机会等要素。尤其是，会议将提供：(1)为初级科学家提供培训机会，以促进陈述技能的发展以及整体科学素质和分析的严谨性；(2)为所有职业级别的科学家提供一个促进有意义的科学互动的亲密环境；(3)在多层次的研究和教育机构中传播知识；(4)共享材料和信息资源；以及(V)开展合作的机会，这可以使来自较小实验室和/或主要来自本科(教学)机构的科学家受益，这些机构可能比主要研究机构的科学家拥有更少的资源和更有限的机会获得尖端技术。

DESCRIPTION (provided by applicant): Research in the past decade has spurred tremendous progress in our understanding of molecular mechanisms that underlie cell function. Advances have come from multiple cell types and organisms. Notably, yeast systems often have been at the forefront in the discovery of new proteins, pathways, structures, and in mechanistic insights. Despite its existence as a unicellular organism, yeast research has also revealed unexpected insights into the physiology of multicellular organisms and the functions of specialized tissues. Yeast cell biology continues to be a vibrant field of research, and yeast systems are critically important to the larger research community by serving as the test bed for new concepts and technologies. The intellectual merit of the meeting series on Yeast Cell Biology (2011, 2013 and 2015) is that it will create a premier forum for the discussion and exchange of cutting-edge discoveries about the internal functions of eukaryotic cells. The program will include eight sessions covering a wide range of topics in cell biology including membrane trafficking, cytoskeleton, the cell cycle, polarity, chromosomes, nuclear organization, and signaling, with a focus on higher order regulation that integrates these diverse events. Each session will be led by two outstanding and well-known investigators in the relevant area. With the exception of short talks presented by the session chairs, all of the talks and posters to be presented will be selected from submitted abstracts, and most of the talks will be given by students, postdoctoral fellows and other junior investigators. It is expected that more than 275 scientists will attend. Of these, over half are likely to be graduate students and postdoctoral fellows. The meeting will serve to provide a stimulating environment for the free flowing discussion of some of the most exciting data and concepts at the frontiers of knowledge in cell biology. Given the rapid pace of developments in the field, this meeting presents an exciting opportunity for participants to learn about recent breakthroughs that will be relevant to their own research both in yeast and in other systems. The broader impacts of the proposed activity are manifold. First, they include the scientific implications for other fields beyond yeast cell biology, as discoveries in this field will continue to foster a rapid pace of fundamental discoveries and insights that impact the physiologies of all life forms. Second, they also include elements of education, training, resource sharing, and opportunities for interaction and collaboration. In particular, the meeting will provide: (i) training opportunities for junior scientists that will promote the development of presentation skills as well as overall scientific quality and analytical rigor; (ii) an intimate setting that will foster meaningful scientific interactions among scientists at all career levels; (iii) the dissemination of knowledge among multiple strata of research and educational institutions; (iv) sharing of resources, both material and informational; and (v) opportunities for the initiation of collaborations, which can benefit scientists from smaller labs and/or from primarily undergraduate (teaching) institutions who may have fewer resources and more limited access to cutting-edge technologies than do scientists from major research institutions.