Biostats

项目总结(见说明)： 生物统计和生物信息学基金(BBF)是生物统计和生物信息学协作及相关方法研究的共享机构资源。2007年7月，作为《气候变化框架公约》内部机制审查进程的结果，生物信息学机制的分析和解释部分与生物统计机制合并，形成“生物统计和生物信息学机制”。该设施 在整个中心范围内被认为是研究基础设施的关键组成部分，并为来自所有五个中心项目的研究人员提供服务。它为中心研究人员提供严格的生物统计学和生物信息学设计、分析和解释实验和研究。设施工作人员在临床试验、临床前研究、生物实验、 在翻译研究和癌症预防和控制问题方面，BBF生物统计学家在研究设计和执行的所有阶段都发挥着基础性作用，BBF生物信息学家为分析和探索各种实验室结果(包括高通量数据)提供最先进的专业知识。 他们与实验室、癌症控制、翻译和临床研究人员的互动扩展了对实验数据的解释，并为fccc的研究活动做出了重大贡献。在这个筹资周期中，招募了六名新的博士级别的BBF成员。2005年1月至2010年6月期间，基金成员共同撰写了145份手稿，合作时间为41,264个小时。BBF成员在临床试验设计、观察性研究方法和高通量数据分析方面发表了13篇方法学/第一作者论文，并应用新的量化方法和先进方法来扩展和支持fccc的研究。在一个例子中。该机构的成员开发了一种新的临床试验设计，允许在疾病快速发展时提前停止，这是治疗无效的迹象。这个设计是 应用于转移性尿路上皮癌的11期随机试验，导致一种无效治疗提前终止，并确定了一种有前景的新联合疗法。2009年，该机制记录了9941个咨询小时，其中78.8%用于支持72名同行审查的资助调查人员。

PROJECT SUMMARY (See instructions): The Biostatistics and Bioinformatics Facility (BBF) is a shared, institutional resource for biostatistics and bioinformatics collaboration and related methodological research. In July 2007, as a result of the FCCC internal Facility review process, the analysis and interpretation components of the Bioinformatics Facility were merged with the Biostatistics Facility to form the "Biostatistics and Bioinformatics Facility". The Facility is recognized Center-wide as a critical component of the research infrastructure and serves investigators from all five Center Programs. It provides Center investigators with rigorous biostatistics and bioinformatics design, analysis and interpretation of experiments and studies. Facility staff are broadly skilled in quantitative and computational methods for clinical trials, pre-clinical studies, biological experiments, translational investigations and cancer prevention and control problems, BBF biostatisticians play a fundamental role in all phases of study design and execution and BBF bioinformaticians provide state-of-theart expertise for the analysis and exploration of diverse laboratory results including high throughput data. Their interactions with laboratory, cancer control, translational and clinical investigators have extended the interpretation of experimental data and contributed substantially to FCCC research activities. Six new Ph.D.-level BBF members were recruited during this funding cycle. Between January 2005 and June 2010, Facility members were coauthors of 145 manuscripts and logged 41,264 collaborative hours. BBF members produced 13 methodology/first author publications In clinical trial design, observational study methods and high throughput data analysis; and applied novel quantitative approaches and advanced methods to extend and support FCCC research. In one example. Facility members developed a novel clinical trial design that permits early stopping for rapid disease progression, an indication of therapeutic futility. This design was employed in a randomized Phase 11 trial in metastatic urothelial carcinoma that resulted in early termination of an ineffective therapy and identification of a promising new combination therapy. In 2009 the Facility logged 9,941 consulting hours with 78.8% in support of 72 peer-reviewed, funded investigators.