Myeloma Plasma Cell Dormancy - 'Eradicating the Sleeping Giant'

多发性骨髓瘤是一种在骨骼中发生的致命癌症。目前的治疗方法最初是有效的，但患者会产生耐药性，疾病会复发。这使得寻找克服耐药性的药物成为优先事项。骨髓瘤细胞可以以休眠状态隐藏在骨骼中，在这种状态下，它们对化疗不敏感。我们已经在休眠细胞中发现了新的药物靶点。我们正在研究这些新的靶点是否可以用来根除骨髓瘤细胞并治愈这种疾病。

Multiple myeloma is a fatal cancer that develops in the skeleton. Current therapies are initially effective, but patients develop resistance and the disease returns. This makes the search for drugs to overcome resistance a priority. Myeloma cells can hide in bone in a dormant state where they are insensitive to chemotherapy. We have identified new drug targets in dormant cells. We are investigating whether these new targets can be used eradicate myeloma cells and cure the disease.