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Characterizing molecular interactomes using TurboID

Characterizing molecular interactomes using TurboID
使用 TurboID 表征分子相互作用组
批准号：
10689616
负责人：
Mark Henderson
金额：
$14.62万
依托单位：
NATIONAL CENTER FOR ADVANCING TRANSLATIONAL SCIENCES
依托单位国家：
美国
项目类别：
财政年份：
--
资助国家：
美国
项目状态：
未结题
起止时间：
至
来源：
https://reporter.nih.gov/project-details/10689616
关键词：
BiotinCollaborationsDiseaseExtramural ActivitiesGoalsInformaticsLabelLigaseModelingMolecularPharmaceutical ChemistryProcessResearchTranslationsUnited States National Institutes of HealthWorkdrug discoveryscreeningsmall moleculetherapeutic developmenttool

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中文摘要
翻译
在此期间，该团队开发了一些工具，以探索TurboID作为邻近标记工具的新用途，以定义相互作用。 这个合作团队的目标是建立在之前开发混杂生物素连接酶TurboID的外部研究的基础上。早期翻译部(ETB)的总体目标是发现新的小分子探针，并通过合作研究的模式催化治疗开发的过程。在每次合作中，NIH和校外疾病专家与ETBS药物发现团队合作，利用他们在小分子筛查、药物化学和信息学方面的专业知识。
英文摘要
During this period, the team has developed tools to explore new uses of TurboID as a proximity labeling tool to define interactomes. This collaborative team aims build on previous extramural research that has developed a promiscuous biotin ligase TurboID. The Early Translation Branch's (ETB) overall goal is to uncover new small molecule probes and catalyze the process of therapeutic development through a model of collaborative research. With each collaboration, NIH and extramural disease experts work with the ETBs drug discovery teams, leveraging their expertise in small molecule screening, medicinal chemistry and informatics.
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